Bexsero® chronicle

被引：78

作者：

Vernikos, George ^{[1
]}

Medini, Duccio ^{[2
]}

机构：

[1] Novartis Hellas SACI, Athens, Greece

[2] Novartis Vaccines, Dept Res, I-53100 Siena, Italy

来源：

PATHOGENS AND GLOBAL HEALTH | 2014年 / 108卷 / 07期

关键词：

Bexsero; 4CMenB; Neisseria meningitidis; Serogroup B meningitis; Meningococcal; Antigen Typing System (MATS); B MENINGOCOCCAL VACCINE; OUTER-MEMBRANE VESICLES; NEISSERIA-MENINGITIDIS; STRAIN COVERAGE; POLYSIALIC ACID; QUANTITATIVE ASSESSMENT; MOLECULAR EPIDEMIOLOGY; BACTERICIDAL ANTIBODY; ROUTINE INFANT; DISEASE;

D O I：

10.1179/2047773214Y.0000000162

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Neisseria meningitidis causes globally 1.2 million invasive disease cases and 135 000 deaths per year, mostly in infants and adolescents. A century of traditional vaccinology had failed the fight against the serogroup B meningococcus (MenB), mostly prevalent in developed countries. Eighteen years after the publication of the first complete genome sequence from a living organism, thanks to an innovative genome-based approach named 'reverse vaccinology', the first broadly effective MenB vaccine was licensed for use by the European Medical Agency and other authorities, and is being implemented worldwide. Here we review this long and passionate journey, from the disease epidemiology to novel antigen discovery, from vaccine clinical development to public health impact: two decades of scientific and technological innovation to defeat one of the most sudden and devastating invasive diseases.

引用

页码：305 / 311

页数：7

共 74 条

[61] Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 In Japan by multilocus sequence typing [J].

Takahashi, H ;

Kuroki, T ;

Watanabe, Y ;

Tanaka, H ;

Inouye, H ;

Yamai, S ;

Watanabe, H .

JOURNAL OF MEDICAL MICROBIOLOGY, 2004, 53 (07) :657-662

[62] Clinical recognition of meningococcal disease in children and adolescents [J].

Thompson, MJ ;

Ninis, N ;

Perera, R ;

Mayon-White, R ;

Phillips, C ;

Bailey, L ;

Harnden, A ;

Mant, D ;

Levin, M .

LANCET, 2006, 367 (9508) :397-403

[63] The natural history of meningococcal carriage and disease [J].

Trotter, C. L. ;

Gay, N. J. ;

Edmunds, W. J. .

EPIDEMIOLOGY AND INFECTION, 2006, 134 (03) :556-566

[64] Human B- and T-cell responses after immunization with a hexavalent PorA meningococcal outer membrane vesicle vaccine [J].

vanderVoort, ER ;

vanDijken, H ;

Kuipers, B ;

vanderBiezen, J ;

vanderLey, P ;

Meylis, J ;

Claassen, I ;

Poolman, J .

INFECTION AND IMMUNITY, 1997, 65 (12) :5184-5190

[65] Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials [J].

Vesikari, Timo ;

Esposito, Susanna ;

Prymula, Roman ;

Ypma, Ellen ;

Kohl, Igor ;

Toneatto, Daniela ;

Dull, Peter ;

Kimura, Alan .

LANCET, 2013, 381 (9869) :825-835

[66]

Vieusseaux M., 1805, J MED CHIR PHARM, V11, P163

[67] Meningococcal disease: Epidemiology and pathogenesis [J].

Virji, M .

TRENDS IN MICROBIOLOGY, 1996, 4 (12) :466-469

[68] Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment [J].

Vogel, Ulrich ;

Taha, Muhamed-Kheir ;

Vazquez, Julio A. ;

Findlow, Jamie ;

Claus, Heike ;

Stefanelli, Paola ;

Caugant, Dominique A. ;

Kriz, Paula ;

Abad, Raquel ;

Bambini, Stefania ;

Carannante, Anna ;

Deghmane, Ala Eddine ;

Fazio, Cecilia ;

Frosch, Matthias ;

Frosi, Giacomo ;

Gilchrist, Stefanie ;

Giuliani, Marzia M. ;

Hong, Eva ;

Ledroit, Morgan ;

Lovaglio, Pietro G. ;

Lucidarme, Jay ;

Musilek, Martin ;

Muzzi, Alessandro ;

Oksnes, Jan ;

Rigat, Fabio ;

Orlandi, Luca ;

Stella, Maria ;

Thompson, Danielle ;

Pizza, Mariagrazia ;

Rappuoli, Rino ;

Serruto, Davide ;

Comanducci, Maurizio ;

Boccadifuoco, Giuseppe ;

Donnelly, John J. ;

Medini, Duccio ;

Borrow, Ray .

LANCET INFECTIOUS DISEASES, 2013, 13 (05) :416-425

[69] Edward Jenner and the eradication of smallpox [J].

Willis, NJ .

SCOTTISH MEDICAL JOURNAL, 1997, 42 (04) :118-121

[70] Meningitis B vaccine to be introduced in UK after U turn on its cost effectiveness [J].

Wise, Jacqui .

BMJ-BRITISH MEDICAL JOURNAL, 2014, 348

← 1 2 3 4 5 6 7 8 →