Bexsero® chronicle

被引：78

作者：

Vernikos, George ^{[1
]}

Medini, Duccio ^{[2
]}

机构：

[1] Novartis Hellas SACI, Athens, Greece

[2] Novartis Vaccines, Dept Res, I-53100 Siena, Italy

来源：

PATHOGENS AND GLOBAL HEALTH | 2014年 / 108卷 / 07期

关键词：

Bexsero; 4CMenB; Neisseria meningitidis; Serogroup B meningitis; Meningococcal; Antigen Typing System (MATS); B MENINGOCOCCAL VACCINE; OUTER-MEMBRANE VESICLES; NEISSERIA-MENINGITIDIS; STRAIN COVERAGE; POLYSIALIC ACID; QUANTITATIVE ASSESSMENT; MOLECULAR EPIDEMIOLOGY; BACTERICIDAL ANTIBODY; ROUTINE INFANT; DISEASE;

D O I：

10.1179/2047773214Y.0000000162

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Neisseria meningitidis causes globally 1.2 million invasive disease cases and 135 000 deaths per year, mostly in infants and adolescents. A century of traditional vaccinology had failed the fight against the serogroup B meningococcus (MenB), mostly prevalent in developed countries. Eighteen years after the publication of the first complete genome sequence from a living organism, thanks to an innovative genome-based approach named 'reverse vaccinology', the first broadly effective MenB vaccine was licensed for use by the European Medical Agency and other authorities, and is being implemented worldwide. Here we review this long and passionate journey, from the disease epidemiology to novel antigen discovery, from vaccine clinical development to public health impact: two decades of scientific and technological innovation to defeat one of the most sudden and devastating invasive diseases.

引用

页码：305 / 311

页数：7

共 74 条

[21] MITOGENIC PROPERTIES OF THYMUS-INDEPENDENT ANTIGEN PNEUMOCOCCAL POLYSACCHARIDE-SIII [J].

COUTINHO, A ;

MOLLER, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1973, 3 (10) :608-613

[22] ADHERENCE OF ISOLATES OF NEISSERIA-MENINGITIDIS FROM PATIENTS AND CARRIERS TO HUMAN BUCCAL EPITHELIAL-CELLS [J].

CRAVEN, DE ;

PEPPLER, MS ;

FRASCH, CE ;

MOCCA, LF ;

MCGRATH, PP ;

WASHINGTON, G .

JOURNAL OF INFECTIOUS DISEASES, 1980, 142 (04) :556-568

[23] Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines [J].

Donnelly, John ;

Medini, Duccio ;

Boccadifuoco, Giuseppe ;

Biolchi, Alessia ;

Ward, Joel ;

Frasch, Carl ;

Moxon, E. Richard ;

Stella, Maria ;

Comanducci, Maurizio ;

Bambini, Stefania ;

Muzzi, Alessandro ;

Andrews, William ;

Chen, Jie ;

Santos, George ;

Santini, Laura ;

Boucher, Philip ;

Serruto, Davide ;

Pizza, Mariagrazia ;

Rappuoli, Rino ;

Giuliani, Marzia Monica .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (45) :19490-19495

[24] The global value of vaccination [J].

Ehreth, J .

VACCINE, 2003, 21 (7-8) :596-600

[25]

EMA, AUTH DET BEXS

[26]

European Centre for Disease Prevention Control, 2011, SURV INV BACT DIS EU

[27]

FINNE J, 1983, LANCET, V2, P355

[28]

FINNE J, 1987, J IMMUNOL, V138, P4402

[29] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

[30] PROTECTION AGAINST GROUP-B MENINGOCOCCAL DISEASE .3. IMMUNOGENICITY OF SEROTYPE 2 VACCINES AND SPECIFICITY OF PROTECTION IN A GUINEA-PIG MODEL [J].

FRASCH, CE ;

ROBBINS, JD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (03) :629-644

← 1 2 3 4 5 6 7 8 →