Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

被引：12

作者：

Christie, Catherine ^{[1
]}

Molina, Stephanie ^{[2
]}

Gonzales, Jonathan ^{[1
]}

Berg, Kristian ^{[3
]}

Nair, Rohit Kumar ^{[1
]}

Huynh, Khoi ^{[1
]}

Madsen, Steen J. ^{[2
]}

Hirschberg, Henry ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst, Irvine, CA 92612 USA

[2] Univ Nevada, Dept Hlth Phys & Diagnost Sci, Las Vegas, NV 89154 USA

[3] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Radiat Biol, Oslo, Norway

来源：

BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 04期

关键词：

CANCER-CELLS; PHOTODYNAMIC THERAPY; PROLIFERATION; GLIOBLASTOMA; ADRIAMYCIN; BLEOMYCIN; RADIATION; PATTERNS; DELIVERY; TUMORS;

D O I：

10.1364/BOE.7.001240

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Combination therapies of photochemical internalization (PCI) and moderate hyperthermia (MHT) were investigated in an in vitro system consisting of human and rat glioma spheroids. PCI using the amphiphilic photosensitizer, AlPcS2a and two anti cancer agents BLM or 5-FU were used. Spheroids were irradiated with lambda = 670 nm laser light in an incubator at temperatures ranging from 37 to 44 degrees C. For each temperature investigated, spheroids were divided into 4 groups: control, drug-only, photodynamic therapy (PDT), and PCI. PDT and PCI spheroids were exposed to radiant exposures ranging from 0.3 to 2.5 J cm(-2) using an irradiance of 5 mW cm(-2). Toxicity was evaluated from spheroid growth kinetics. The combination of PCI and MHT resulted in significant increases in BLM efficacy at 44 degrees C for both cell line derived spheroids compared to controls at 37 degrees C over the range of radiant exposures examined. 5-FU PCI was ineffective for the human cell line at both 37 and 44 degrees C. (C) 2016 Optical Society of America

引用

页码：1240 / 1250

页数：11

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