The role of helper innate lymphoid cells in cancer

被引：5

作者：

Hu, Shunfeng ^{[1
]}

Wang, Xin ^{[1
,2
,3
,4
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Hematol, Jinan, Shandong, Peoples R China

[2] Shandong Univ, Sch Med, Jinan 250012, Shandong, Peoples R China

[3] Shandong Prov Engn Res Ctr Lymphoma, Jinan 250021, Shandong, Peoples R China

[4] Key Lab Kidney Regenerat Shandong Prov, Jinan 250021, Shandong, Peoples R China

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 12期

关键词：

immunology; innate lymphoid cells; interaction; therapy; tumor; TRANSCRIPTION FACTOR GATA3; TISSUE-INDUCER CELLS; T-CELLS; TYPE-2; IMMUNITY; STEM-CELLS; TUFT CELLS; DIFFERENTIATION; ACTIVATION; INITIATION; DISTINCT;

D O I：

10.2217/imt-2019-0048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) are an emerging family of innate immune cells and have been found to have an important role in infection, inflammation and tissue repair. In particular, recent work has identified significant alterations of ILC responses in tumor patients, suggesting potential roles of ILCs in tumor development. In this paper, we have focused on the basic features of ILCs and their interaction with other immune cells. Importantly, as the role of cytotoxic natural killer cells, assigned to ILC1 family, in cancer has been well established, we have summarized the new findings that showcase the potential role and mechanism of helper ILCs in different tumors. Helper ILCs might promote or inhibit tumor growth and metastasis, which depends on tumor type and ILC subset.

引用

页码：1067 / 1081

页数：15

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