SyncPro : A Synchronized Visualization Tool for Differential Analysis of Proteomics Data Sets

被引:0
作者
Yung, Ling Sing [1 ]
Yang, Chao [1 ]
Dakna, Mohammed [2 ]
Mischak, Harald [2 ]
Yu, Weichuan [1 ]
机构
[1] Hong Kong Univ Sci & Technol, Dept Elect & Comp Engn, Hong Kong, Hong Kong, Peoples R China
[2] Mosa Diagnost & Therapeut, Hannover, Germany
来源
2010 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS (BIBMW) | 2010年
关键词
Visualization; Proteomics; Mass Spectrometry; MASS-SPECTROMETRY DATA; LC-MS; SOFTWARE;
D O I
暂无
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
In the comparative proteomics studies, visualization has become an emerging technique in the analysis. It provides an intuitive overview of large-scale mass spectrometry data sets with possibilities to further explore data details at different levels. While different visualization tools have already been developed, they are often designed to handle one or a few mass spectrometry data sets. Apparently, this is not enough as many proteomics studies involve many samples. It is much desired to simultaneously visualize all data sets in order to better examine data sets. In this paper, we present a visualization tool named SyncPro for differential analysis of multiple pre-processed proteomics data sets. It offers features to (i) compare many dIlta sets simultaneously; (ii) facilitate data exploration through selection and extraction; (iii) quickly judge the quality of selected features. Our proposed method further enhances the functions of existing visualization tools.
引用
收藏
页码:95 / 100
页数:6
相关论文
共 14 条
[1]   A suite of algorithms for the comprehensive analysis of complex protein mixtures using high-resolution LC-MS [J].
Bellew, Matthew ;
Coram, Marc ;
Fitzgibbon, Matthew ;
Igra, Mark ;
Randolph, Tim ;
Wang, Pei ;
May, Damon ;
Eng, Jimmy ;
Fang, Ruihua ;
Lin, ChenWei ;
Chen, Jinzhi ;
Goodlett, David ;
Whiteaker, Jeffrey ;
Paulovich, Amanda ;
McIntosh, Martin .
BIOINFORMATICS, 2006, 22 (15) :1902-1909
[2]   mzML: A single, unifying data format for mass spectrometer output [J].
Deutsch, Eric .
PROTEOMICS, 2008, 8 (14) :2776-2777
[3]   Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data [J].
Jaitly, Navdeep ;
Mayampurath, Anoop ;
Littlefield, Kyle ;
Adkins, Joshua N. ;
Anderson, Gordon A. ;
Smith, Richard D. .
BMC BIOINFORMATICS, 2009, 10
[4]   MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data [J].
Katajamaa, M ;
Miettinen, J ;
Oresic, M .
BIOINFORMATICS, 2006, 22 (05) :634-636
[5]   A tool to visualize and evaluate data obtained by liquid chromatography-electrospray ionization-mass spectrometry [J].
Li, XJ ;
Pedrioli, PGA ;
Eng, J ;
Martin, D ;
Yi, EC ;
Lee, H ;
Aebersold, R .
ANALYTICAL CHEMISTRY, 2004, 76 (13) :3856-3860
[6]   Visual analysis of gel-free Proteome data [J].
Linsen, L ;
Löcherbach, J ;
Berth, M ;
Becher, D ;
Bernhardt, J .
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS, 2006, 12 (04) :497-508
[7]   MASIC: A software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(/MS) features [J].
Monroe, Matthew E. ;
Shaw, Jason L. ;
Daly, Don S. ;
Adkins, Joshua N. ;
Smith, Richard D. .
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2008, 32 (03) :215-217
[8]   VIPER: an advanced software package to support high-throughput LC-MS peptide identification [J].
Monroe, Matthew E. ;
Tolic, Nikola ;
Jaitly, Navdeep ;
Shaw, Jason L. ;
Adkins, Joshua N. ;
Smith, Richard D. .
BIOINFORMATICS, 2007, 23 (15) :2021-2023
[9]   MSQuant, an Open Source Platform for Mass Spectrometry-Based Quantitative Proteomics [J].
Mortensen, Peter ;
Gouw, Joost W. ;
Olsen, Jesper V. ;
Ong, Shao-En ;
Rigbolt, Kristoffer T. G. ;
Bunkenborg, Jakob ;
Cox, Juergen ;
Foster, Leonard J. ;
Heck, Albert J. R. ;
Blagoev, Blagoy ;
Andersen, Jens S. ;
Mann, Matthias .
JOURNAL OF PROTEOME RESEARCH, 2010, 9 (01) :393-403
[10]   MSight: An image analysis software for liquid chromatography-mass spectrometry [J].
Palagi, PM ;
Walther, D ;
Quadroni, M ;
Catherinet, S ;
Burgess, J ;
Zimmermann-Ivol, CG ;
Sanchez, JC ;
Binz, PA ;
Hochstrasser, DF ;
Appel, RD .
PROTEOMICS, 2005, 5 (09) :2381-2384