Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate-2,2′-Bipyridyl

被引：12

作者：

Fujioka, Hiromichi ^{[1
]}

Senami, Kento ^{[1
]}

Kubo, Ozora ^{[1
]}

Yahata, Kenzo ^{[1
]}

Minamitsuji, Yutaka ^{[1
]}

Maegawa, Tomohiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 03期

基金：

日本学术振兴会;

关键词：

deprotection; methylene acetal; diol; 2,2 '-bipyridyl; pyridinium intermediate; EFFICIENT DEPROTECTION; ETHERS;

D O I：

10.1248/cpb.58.426

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The facile deprotection of methylene acetal protection of diols tinder mild conditions is established. The combination of trimethylsilyl triflate (TMSOTf) and 2,2'-bipyridyl followed by a weakly acidic hydrolysis is-as effective and the substrates having acid sensitive functional groups can be tolerated under the stated conditions. The selective deprotection between methylene acetal and benzophenone ketal was achieved.

引用

页码：426 / 428

页数：3

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