Fabrication of polyhydroxybutyrate (PHB)/γ-Fe2O3 nanocomposite film and its properties study

被引:14
作者
Moghaddam, Shokooh [1 ]
Khorasani, Mohammad Taghi [2 ]
Hosseinkazemi, Hesam [3 ]
Biazar, Esmaeil [4 ]
Fazeli, Mahyar [5 ]
机构
[1] Islamic Azad Univ, Sci & Res Branch, Biomat Dept, Tehran, Iran
[2] Iran Polymer & Petrochem Inst, Biomat Dept, Tehran, Iran
[3] Amirkabir Univ Technol, Dept Tissue Engn, Fac Biomed Engn, Tehran, Iran
[4] Islamic Azad Univ, Tonekabon Branch, Fac Biomed Engn, Tonekabon, Iran
[5] Univ Fed Rio de Janeiro, Dept Mat Sci & Engn, Rio De Janeiro, Brazil
关键词
Magnetic nanocomposite; polyhydroxybuthyrate (PHB); gamma-Fe2O3; nanoparticles; physical and mechanical analyses; cell separation; RAT SCIATIC-NERVE; NANOFIBROUS PHBV TUBE; MAGNETIC NANOPARTICLES; TUMOR-CELLS; REGENERATION; SEPARATION; SCAFFOLD; BLOOD; GRAFT;
D O I
10.1080/09205063.2016.1143320
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Magnetic separation has numerous advantages in isolating cancerous and normal cells used in the diagnosis and treatment sectors. Here, we produced magnetic nanocomposite films made of polyhydroxybutyrate (PHB)/magnetite nanoparticles (gamma-Fe2O3), and the properties of the films by SEM, TEM, FTIR, DMTA, contact angle, and cellular analyses were investigated. The microscopic images showed uniform distribution of gamma-Fe2O3 magnetic nanoparticles in polymeric matrix. The chemical bounds between magnetic nanoparticles and polymeric matrix demonstrated using the FTIR spectrophotometer. The DMTA and contact angle results indicated an increase in the glass transition temperature and hydrophilic properties of nanocomposites is achieved by increasing the magnetic nanoparticles amount in polymer matrix. The cellular results were showed that adhesion of cancer cells compared to normal cells was significantly enhanced by the induction of a magnetic field. These nanocomposite films can be used as a substrate for cellular adhesion and separation processes.
引用
收藏
页码:793 / 804
页数:12
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