Epigenetic reprograming of immune cells through selective inhibition of HDAC6 reduces suppressive phenotypes and augments anti-tumor properties of T-cells

被引：1
|
作者：
Sodre, Andressa L.
Woods, David M.
Sarnaik, Amod
Betts, Brian C.
Quayle, Steven
Jones, Simon
Weber, Jeffrey
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-638
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
638
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Inhibition of TET (Ten-Eleven Translocation) enzymes enhances systemic anti-tumor immune responses in T cells
    Seo, Hyungseok
    Yang, Chao
    Zhang, Wade
    Hogan, Patrick
    Rao, Anjana
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01)
  • [32] PROLIFERATION INVITRO OF T-CELLS WITH ANTI-TUMOR ACTIVITY FROM GUINEA-PIGS IMMUNE TO LINE-10 HEPATOMA
    SHU, S
    HUNTER, JT
    EVANS, CH
    RAPP, HJ
    FEDERATION PROCEEDINGS, 1980, 39 (03) : 922 - 922
  • [33] HDAC6 INHIBITION AUGMENTS THE EFFICACY OF ANTI-CD20 MONOCLONAL ANTIBODIES BY UP-REGULATING CD20 LEVEL IN MALIGNANT B-CELLS
    Bobrowicz, M.
    Dwojak, M.
    Bojarczuk, K.
    Siernicka, M.
    Winiarska, M.
    Golab, J.
    HAEMATOLOGICA, 2014, 99 : 437 - 437
  • [34] The histone deacetylase inhibitor LBH589 augments anti-tumor immunity through direct effects on tumor and immune cells leading to impaired tumor progression in vivo
    Woods, David M.
    Woan, Karrune V.
    Wang, Hongwei
    Cheng, Fengdong
    Wang, Zi
    Vazquez, Lianet
    Perez, Patricio
    Lienlaf, Maritza
    Rock-Klotz, Jennifer
    Sahakian, Eva
    Powers, John
    Deng, Susan
    Oscar, Merino
    Atadja, Peter
    Seto, Ed
    Pinilla-Ibarz, Javier
    Weber, Jeffrey S.
    Sotomayor, Eduardo M.
    Villagra, Alejandro
    CANCER RESEARCH, 2012, 72
  • [35] Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
    Knox, Tessa
    Sahakian, Eva
    Banik, Debarati
    Hadley, Melissa
    Palmer, Erica
    Noonepalle, Satish
    Kim, Jennifer
    Powers, John
    Gracia-Hernandez, Maria
    Oliveira, Vasco
    Cheng, Fengdong
    Chen, Jie
    Barinka, Cyril
    Pinilla-Ibarz, Javier
    Lee, Norman H.
    Kozikowski, Alan
    Villagra, Alejandro
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [36] Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
    Tessa Knox
    Eva Sahakian
    Debarati Banik
    Melissa Hadley
    Erica Palmer
    Satish Noonepalle
    Jennifer Kim
    John Powers
    Maria Gracia-Hernandez
    Vasco Oliveira
    Fengdong Cheng
    Jie Chen
    Cyril Barinka
    Javier Pinilla-Ibarz
    Norman H. Lee
    Alan Kozikowski
    Alejandro Villagra
    Scientific Reports, 9
  • [37] Durable T-cell-mediated anti-tumor immune response to pancreatic cancer cells overexpressing interleukin 6
    Arneson-Wissink, Paige C.
    Bartlett, Alexandra Q.
    Mendez, Heike
    Zhu, Xinxia
    Dickie, Jessica
    McWhorter, Matthew
    Levasseur, Peter R.
    Diba, Parham
    Byrne, Katelyn T.
    Scott, Gregory D.
    Eil, Robert
    Grossberg, Aaron J.
    CANCER RESEARCH, 2024, 84 (17)
  • [38] PLX-4107, a selective IKZF2 degrader, reprograms suppressive regulatory T cells and demonstrates anti-tumor activity.
    Thompson, Peggy A.
    Yang, Pengyu
    Yang, Linette
    Song, Susan
    Huang, Yujun
    Li, Xiaoming
    Dearie, Alejandro
    Chien, Stephen
    Spalding, Mary E.
    Blanco, Gabrielle
    Daniele, Elizabeth
    Toth, Julia
    Jamborcic, Aleksandar
    Parker, Gregory
    Bailey, Simon
    CANCER IMMUNOLOGY RESEARCH, 2022, 10 (12)
  • [39] Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+T cells
    Gomez-Aleza, Clara
    Nguyen, Bastien
    Yoldi, Guillermo
    Ciscar, Marina
    Barranco, Alexandra
    Hernandez-Jimenez, Enrique
    Maetens, Marion
    Salgado, Roberto
    Zafeiroglou, Maria
    Pellegrini, Pasquale
    Venet, David
    Garaud, Soizic
    Trinidad, Eva M.
    Benitez, Sandra
    Vuylsteke, Peter
    Polastro, Laura
    Wildiers, Hans
    Simon, Philippe
    Lindeman, Geoffrey
    Larsimont, Denis
    Van den Eynden, Gert
    Velghe, Chloe
    Rothe, Francoise
    Willard-Gallo, Karen
    Michiels, Stefan
    Munoz, Purificacion
    Walzer, Thierry
    Planelles, Lourdes
    Penninger, Josef
    Azim, Hatem A., Jr.
    Loi, Sherene
    Piccart, Martine
    Sotiriou, Christos
    Gonzalez-Suarez, Eva
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [40] Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells
    Clara Gómez-Aleza
    Bastien Nguyen
    Guillermo Yoldi
    Marina Ciscar
    Alexandra Barranco
    Enrique Hernández-Jiménez
    Marion Maetens
    Roberto Salgado
    Maria Zafeiroglou
    Pasquale Pellegrini
    David Venet
    Soizic Garaud
    Eva M. Trinidad
    Sandra Benítez
    Peter Vuylsteke
    Laura Polastro
    Hans Wildiers
    Philippe Simon
    Geoffrey Lindeman
    Denis Larsimont
    Gert Van den Eynden
    Chloé Velghe
    Françoise Rothé
    Karen Willard-Gallo
    Stefan Michiels
    Purificación Muñoz
    Thierry Walzer
    Lourdes Planelles
    Josef Penninger
    Hatem A. Azim
    Sherene Loi
    Martine Piccart
    Christos Sotiriou
    Eva González-Suárez
    Nature Communications, 11
12345