Review of the biological properties and toxicity of usnic acid

被引：122

作者：

Araujo, A. A. S. ^{[1
]}

de Melo, M. G. D. ^{[1
]}

Rabelo, T. K. ^{[2
]}

Nunes, P. S. ^{[1
]}

Santos, S. L. ^{[1
]}

Serafini, M. R. ^{[3
]}

Santos, M. R. V. ^{[1
]}

Quintans-Junior, L. J. ^{[1
]}

Gelain, D. P. ^{[3
]}

机构：

[1] Univ Fed Sergipe, Sao Cristovao, Brazil

[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil

[3] Univ Fed Sergipe, Lagarto, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 23期

关键词：

usnic acid; lichen; biological activity; antioxidant; antimicrobial; LICHEN SECONDARY METABOLITES; IN-VITRO; (+)-USNIC ACID; ANTIMYCOBACTERIAL ACTIVITY; CLADONIA-SUBSTELLATA; DIETARY-SUPPLEMENT; LIVER-FAILURE; DRUG; HEPATOCYTES; INDOMETHACIN;

D O I：

10.1080/14786419.2015.1007455

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Since its first isolation in 1844, usnic acid [2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl1,3(2H, 9bH)-dibenzo-furandione] has become the most extensively studied lichen metabolite and one of the few that are commercially available. Lichens belonging to usnic acid-containing genera have been used as crude drugs throughout the world. There are indications of usnic acid being a potentially interesting candidate for such activities as anti-inflammatory, analgesic, healing, antioxidant, antimicrobial, antiprotozoal, antiviral, larvicidal and UV protection. However, some studies reported the liver toxicity and contact allergy. Thus, further studies are needed to establish the efficacy and safety of usnic acid

引用

页码：2167 / 2180

页数：14