Review of the biological properties and toxicity of usnic acid

被引：122

作者：

Araujo, A. A. S. ^{[1
]}

de Melo, M. G. D. ^{[1
]}

Rabelo, T. K. ^{[2
]}

Nunes, P. S. ^{[1
]}

Santos, S. L. ^{[1
]}

Serafini, M. R. ^{[3
]}

Santos, M. R. V. ^{[1
]}

Quintans-Junior, L. J. ^{[1
]}

Gelain, D. P. ^{[3
]}

机构：

[1] Univ Fed Sergipe, Sao Cristovao, Brazil

[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil

[3] Univ Fed Sergipe, Lagarto, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 23期

关键词：

usnic acid; lichen; biological activity; antioxidant; antimicrobial; LICHEN SECONDARY METABOLITES; IN-VITRO; (+)-USNIC ACID; ANTIMYCOBACTERIAL ACTIVITY; CLADONIA-SUBSTELLATA; DIETARY-SUPPLEMENT; LIVER-FAILURE; DRUG; HEPATOCYTES; INDOMETHACIN;

D O I：

10.1080/14786419.2015.1007455

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Since its first isolation in 1844, usnic acid [2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl1,3(2H, 9bH)-dibenzo-furandione] has become the most extensively studied lichen metabolite and one of the few that are commercially available. Lichens belonging to usnic acid-containing genera have been used as crude drugs throughout the world. There are indications of usnic acid being a potentially interesting candidate for such activities as anti-inflammatory, analgesic, healing, antioxidant, antimicrobial, antiprotozoal, antiviral, larvicidal and UV protection. However, some studies reported the liver toxicity and contact allergy. Thus, further studies are needed to establish the efficacy and safety of usnic acid

引用

页码：2167 / 2180

页数：14

共 71 条

[21] Severe hepatotoxicity associated with the dietary supplement LipoKinetix
Favreau, JT
Ryu, ML
Braunstein, G
Orshansky, G
Park, SS
Coody, GL
Love, LA
Fong, TL
[J]. ANNALS OF INTERNAL MEDICINE, 2002, 136 (08) : 590 - 595
[22] Fernandes VA, 2013, AVALIACAO EFEITO TRA
[23] Foti RS, 2008, XENOBIOTICA, V38, P264, DOI [10.1080/00498250701802514, 10.1080/00498250701802514 ]
[24] Activity of compounds isolated from Chilean lichens against experimental cutaneous leishmaniasis
Fournet, A
Ferreira, ME
deArias, AR
deOrtiz, ST
Inchausti, A
Yaluff, G
Quilhot, W
Fernandez, E
Hidalgo, ME
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1997, 116 (01): : 51 - 54
[25] Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats
Halici, M
Odabasoglu, F
Suleyman, H
Cakir, A
Aslan, A
Bayir, Y
[J]. PHYTOMEDICINE, 2005, 12 (09) : 656 - 662
[26] Are polyphenols antioxidants or pro-oxidants?: What do we learn from cell culture and in vivo studies?
Halliwell, Barry
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2008, 476 (02) : 107 - 112
[27] Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress
Han, D
Matsumaru, K
Rettori, D
Kaplowitz, N
[J]. BIOCHEMICAL PHARMACOLOGY, 2004, 67 (03) : 439 - 451
[28] HISA T, 1995, CONTACT DERMATITIS, V33, P271, DOI 10.1111/j.1600-0536.1995.tb00483.x
[29] Anti-inflammatory Effects and Mechanisms of Usnic Acid
Huang Zhijun
Zheng Guohua
Tao Junyan
Ruan Jinlan
[J]. JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 2011, 26 (05): : 955 - 959
[30] Usnic acid
Ingólfsdóttir, K
[J]. PHYTOCHEMISTRY, 2002, 61 (07) : 729 - 736

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