Review of the biological properties and toxicity of usnic acid

被引：127
作者：
Araujo, A. A. S. [1 ]
de Melo, M. G. D. [1 ]
Rabelo, T. K. [2 ]
Nunes, P. S. [1 ]
Santos, S. L. [1 ]
Serafini, M. R. [3 ]
Santos, M. R. V. [1 ]
Quintans-Junior, L. J. [1 ]
Gelain, D. P. [3 ]
机构：
[1] Univ Fed Sergipe, Sao Cristovao, Brazil
[2] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
[3] Univ Fed Sergipe, Lagarto, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 23期
关键词：
usnic acid; lichen; biological activity; antioxidant; antimicrobial; LICHEN SECONDARY METABOLITES; IN-VITRO; (+)-USNIC ACID; ANTIMYCOBACTERIAL ACTIVITY; CLADONIA-SUBSTELLATA; DIETARY-SUPPLEMENT; LIVER-FAILURE; DRUG; HEPATOCYTES; INDOMETHACIN;
D O I：
10.1080/14786419.2015.1007455
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Since its first isolation in 1844, usnic acid [2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl1,3(2H, 9bH)-dibenzo-furandione] has become the most extensively studied lichen metabolite and one of the few that are commercially available. Lichens belonging to usnic acid-containing genera have been used as crude drugs throughout the world. There are indications of usnic acid being a potentially interesting candidate for such activities as anti-inflammatory, analgesic, healing, antioxidant, antimicrobial, antiprotozoal, antiviral, larvicidal and UV protection. However, some studies reported the liver toxicity and contact allergy. Thus, further studies are needed to establish the efficacy and safety of usnic acid
引用
收藏
页码：2167 / 2180
页数：14
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