Synthesis and characterisation of mixed-ligand platinum(II)-sulfoxide complexes, [PtCl(DMSO)(L)], for potential use as chemotherapeutic agents (HL = N,N-dialkyl-N′-(3-R-benzoyl)thiourea)

A novel series of mixed-ligand platinum(II) complexes of the type [PtCl(DMSO)(L)], where HL = N,N-diethyl-N'-(3-R-benzoyl)thiourea, N,N-di(2-hydroxyethyl)-N'-(3-R-benzoyl)thiourea or N-morpholino-N'-(3-R-benzoyl)thiourea (R = H, Cl, NO2, CH3O, CH3), have been synthesised and characterised by elemental analysis, IR spectroscopy and H-1 and Pt-195 NMR spectroscopy. The spectroscopic data are consistent with the complexes containing an O, S chelated ligand and an S-bonded sulfoxide ligand which is in a cis arrangement to that of the sulfur donor atom of the chelated ligand. Trends in the NMR spectra can be correlated with the electronic effects of the substituents on the phenyl ring of the acylthiourea ligands. (C) 2000 Elsevier Science S.A. All rights reserved.