Effect of strontium and gelatin on the reactivity of α-tricalcium phosphate

被引：32

作者：

Boanini, E. ^{[1
]}

Panzavolta, S. ^{[1
]}

Rubini, K. ^{[1
]}

Gandolfi, M. ^{[1
]}

Bigi, A. ^{[1
]}

机构：

[1] Univ Bologna, Dept Chem G Ciamician, I-40126 Bologna, Italy

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 03期

关键词：

Calcium phosphate; Gelatin; Strontium; Hydrolysis; IN-VITRO BIOACTIVITY; OCTACALCIUM PHOSPHATE; BONE-FORMATION; PARTICLE-SIZE; CEMENTS; HYDROXYAPATITE; HYDROLYSIS; RATS; CRYSTALLINITY; KINETICS;

D O I：

10.1016/j.actbio.2009.10.014

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The hydrolysis reaction of alpha-tricalcium phosphate (alpha-TCP) is of great interest because of its widespread use in the preparation of biomaterials for hard tissue repair The aim of this study was to investigate how this reaction is influenced by the presence of a bioactive ion, Sr2-, and of a biopolymer. gelatin, which were previously reported to affect the setting reaction of alpha-TCP-based cements Hydrolysis experiments were carried out at different Sr2+ concentrations (0, 5, 10, 20 at.%) in solutions at different gelatin concentrations (0, 0.1, 0.5, 1.0 wt %) The results indicate that Sr2- delays the conversion of alpha-TCP into calcium-deficient hydroxyapatite (CDHA) The structural and morphological modifications of CDHA obtained from solutions at increasing Sr2+ concentrations indicate that during hydrolysis strontium enters the structure of CDHA, where it partially substitutes for calcium Oil the contrary, alpha-TCP hydrolysis rate increases on increasing gelatin concentration Gelatin promotes conversion of alpha-TCP into octacalcium phosphate, and strongly interacts with the nucleating and growing crystals. (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved

引用

页码：936 / 942

页数：7

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