Assessment of oxygen transport and utilization in dogs with naturally occurring sepsis

Objective-To compare cardiac index (CI), oxygen delivery index ((D)over doto(2)I), oxygen extraction ratio (O(2)ER), oxygen consumption index ((V)over doto(2)I), and systemic vascular resistance index (SVRI) in dogs with naturally occurring sepsis with published values for healthy dogs; compare those variables in dogs with sepsis that did or did not survive; and compare CI and (D)over doto(2)I in dogs with sepsis with values in dogs with nonseptic systemic inflammatory response syndrome (nSIRS). Design-Cohort study. Animals-10 dogs with naturally occurring sepsis and 11 dogs with nSIRS. Procedures-Over 24 hours, CI, (D)over doto(2)I, O(2)ER, (V)over doto(2)I, and SVRI were measured 4 and 5 times in dogs with sepsis and with nSIRS, respectively. The mean values of each variable in each group were compared over time and between groups; data for dogs with sepsis that did or did not survive were also compared. Results-Mean (D)over doto(2)I was significantly decreased, and mean CI, O(2)ER, (V)over doto(2)I, and SVRI were not significantly diffvent in dogs with sepsis, compared with published values for healthy dogs. Mean CI and (D)over doto(2)I in dogs with sepsis were significantly greater than valyes in dogs with nSIRS. Among dogs with sepsis that did or did not survive, values of CI, (D)over doto(2)I, O(2)ER, (V)over doto(2)I and SVRI did not differ significantly. Conclusions and Clinical Relevance-Compared with values in healthy dogs, only 6021 was significantly lower in dogs with sepsis. Values of CI and (D)over doto(2)I were significantly higher in dogs with sepsis than in dogs with nSIRS, suggesting differing degrees of myocardial dysfunction between these groups. (J Am Vet Med Assoc 2010;237:167-173)