A microfluidic device based on droplet storage for screening solubility diagrams

被引：91

作者：

Laval, Philippe ^{[1
]}

Lisai, Nicolas ^{[1
]}

Salmon, Jean-Baptiste ^{[1
]}

Joanicot, Mathieu ^{[1
]}

机构：

[1] Unite Mixte Rhodia CNRS Bordeaux 1, LOF, F-33608 Pessac, France

来源：

LAB ON A CHIP | 2007年 / 7卷 / 07期

关键词：

D O I：

10.1039/b700799j

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 mu L of solution.

引用

页码：829 / 834

页数：6

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