Synthesis of Highly Substituted Isoquinolone Derivatives by Nickel-Catalyzed Annulation of 2-Halobenzamides with Alkynes

被引：100

作者：

Liu, Chuan-Che ^{[1
]}

Parthasarathy, Kanniyappan ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

EFFICIENT ROUTE; REGIOSELECTIVE SYNTHESIS; CONCISE SYNTHESIS; BICYCLIC ALKENES; CYCLIZATION; COMPLEXES; ALKALOIDS; ACID;

D O I：

10.1021/ol101371c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the total synthesis of oxyavicine with excellent yield.

引用

页码：3518 / 3521

页数：4

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