Expanding the Role of the Virome: Commensalism in the Gut

被引：46

作者：

Cadwell, Ken ^{[1
]}

机构：

[1] New York Univ Sch Med, Dept Microbiol, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10016 USA

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 04期

基金：

美国国家卫生研究院;

关键词：

INFLAMMATORY-BOWEL-DISEASE; ENTERIC VIRUS; GENE ATG16L1; MICROBIOTA; INFECTION; BACTERIA; MOUSE; CELLS;

D O I：

10.1128/JVI.02966-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viruses affect host physiology beyond causing acute disease, thereby giving rise to the concept that the virome is a component of the microbiome. However, the role of the enteric virome is understudied relative to the fast-paced research examining commensal bacteria in the intestine. In this article, I discuss our recent work on murine norovirus indicating that an animal virus in the intestine can provide many of the signals to the host that have been attributed to commensal bacteria. Our findings suggest that the surge in microbiome research should incorporate examination of the enteric virome.

引用

页码：1951 / 1953

页数：3

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