Diverse structures, functions and uses of FK506 binding proteins

被引：62

作者：

Bonner, Julia Maeve

Boulianne, Gabrielle L. ^{[1
]}

机构：

[1] Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Program Dev & Stem Cell Biol, 686 Bay St, Toronto, ON M5G 0A4, Canada

来源：

CELLULAR SIGNALLING | 2017年 / 38卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

FK506; FK506 binding protein (FKBP); Immunophilin; Peptidyiprolyl cis/trans isomerase; CALCIUM-RELEASE CHANNEL; PEPTIDYL-PROLYL-ISOMERASE; HSP90-BINDING IMMUNOPHILIN FKBP52; POSTTRAUMATIC-STRESS-DISORDER; RYANODINE RECEPTOR FUNCTION; AMYLOID PRECURSOR PROTEIN; CIS-TRANS ISOMERASE; T-CELL-ACTIVATION; FK506-BINDING PROTEIN; GLUCOCORTICOID-RECEPTOR;

D O I：

10.1016/j.cellsig.2017.06.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression requires the formation of a complex between FK506, a FK506 binding protein (FKBP) and calcineurin. Numerous FKBPs have been identified in a wide range of species, from single celled organisms to humans. FKBPs show peptidylprolyl cis/trans isomerase (PPIase) activity and have been shown to affect a wide range of cellular processes including protein folding, receptor signaling and apoptosis. FKBPs also affect numerous biological functions in addition to immunosuppression including regulation of cardiac function, neuronal function and development and have been implicated in several diseases including cardiac disease, cancer and neurodegenerative diseases such as Alzheimer's disease. More recently, FKBPs have proven useful as molecular tools for studying protein interactions, localization and functions. This review provides an overview of the current state of knowledge of FKBPs and their numerous biological functions and uses.

引用

页码：97 / 105

页数：9

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