Site-Tunable Csp3- H Bonds Functionalization by Visible-Light-Induced Radical Translocation of N-Alkoxyphthalimides

被引：59

作者：

Wang, Chuanyong ^{[1
]}

Yu, Yangyang ^{[1
]}

Liu, Wen-Long ^{[1
]}

Duan, Wei-Liang ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, 180 Siwangting Rd, Yangzhou 225002, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

基金：

中国国家自然科学基金;

关键词：

CU-BASED SENSITIZERS; PHOTOREDOX CATALYSIS; RELAY CYCLIZATIONS; ALCOHOLS; GENERATION; ARYLATION; CONSTRUCTION; DERIVATIVES; ALKYLATION; ACTIVATION;

D O I：

10.1021/acs.orglett.9b03524

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Site-tunable functionalization of C(sp(3))-H bonds has been accomplished through radical translocation and cross-coupling. Upon irradiation with visible light, copper-based. photocatalyst [Cu(Xantphos)(dmp)]BF4 enabled cross-coupling of N-alkoxyphthalimides with amino acid esters or amino acids to provide delta-C(sp(3))-H alkylated alcohols (31 examples, up to 92% yield) with additive BNDHP or alpha-C(sp(3))-H alkylated alcohols (18 examples, up to 86% yield) with additive DABCO in a highly regioselective fashion.

引用

页码：9147 / 9152

页数：6

共 79 条

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