Matrix metalloproteinase inhibitors 1998

被引：123

作者：

Beckett, RP ^{[1
]}

Whittaker, M ^{[1
]}

机构：

[1] British Biotech Pharmaceut Ltd, Dept Med Chem, Oxford OX4 5LY, England

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1998年 / 8卷 / 03期

关键词：

arthritis; cancer; collagenase; gelatinase; matrix metalloproteinase; stromelysin; tumour necrosis factor-alpha;

D O I：

10.1517/13543776.8.3.259

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inhibition of matrix metalloproteinases (MMPs) as an approach to treatment of diseases such as cancer, arthritis and multiple sclerosis (MS) is now an area of intense interest within the pharmaceutical industry. This review summarises developments in the design and clinical evaluation of synthetic MMP inhibitors since the subject was last covered in this journal in 1996.

引用

页码：259 / 282

页数：24

共 85 条

[1]

ABREO MA, 1997, 213 ACS NAT M SAN FR

[2] Molecular recognition of protein-ligand complexes: Applications to drug design [J].

Babine, RE ;

Bender, SL .

CHEMICAL REVIEWS, 1997, 97 (05) :1359-1472

[3] Selective inhibition of low affinity IgE receptor (CD23) processing [J].

Bailey, S ;

Bolognese, B ;

Buckle, DR ;

Faller, A ;

Jackson, S ;

Louis-Flamberg, P ;

McCord, M ;

Mayer, RJ ;

Marshall, LA ;

Smith, DG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (01) :29-34

[4] Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing [J].

Bailey, S ;

Bolognese, B ;

Buckle, DR ;

Faller, A ;

Jackson, S ;

Louis-Flamberg, P ;

McCord, M ;

Mayer, RJ ;

Marshall, LA ;

Smith, DG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (01) :23-28

[5] A novel linkage for the solid-phase synthesis of hydroxamic acids [J].

Bauer, U ;

Ho, WB ;

Koskinen, AMP .

TETRAHEDRON LETTERS, 1997, 38 (41) :7233-7236

[6] A novel series of matrix metalloproteinase inhibitors for the treatment of inflammatory disorders [J].

Baxter, AD ;

Bird, J ;

Bhogal, R ;

Massil, T ;

Minton, KJ ;

Montana, J ;

Owen, DA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (07) :897-902

[7] Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety [J].

Baxter, AD ;

Bhogal, R ;

Bird, JB ;

Buckley, GM ;

Gregory, DS ;

Hedger, PC ;

Manallack, DT ;

Massil, T ;

Minton, KJ ;

Montana, JG ;

Neidle, S ;

Owen, DA ;

Watson, RJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (21) :2765-2770

[8]

Beckett RP, 1996, EXPERT OPIN THER PAT, V6, P1305

[9] Recent advances in matrix metalloproteinase inhibitor research [J].

Beckett, RP ;

Davidson, AH ;

Drummond, AH ;

Huxley, P ;

Whittaker, M .

DRUG DISCOVERY TODAY, 1996, 1 (01) :16-26

[10]

BENDER SL, 1997, 214 ACS M LAS VEG 7

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