Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells

被引：13
作者：
Peng, Meixi [1 ]
Huang, Yongxiu [2 ,3 ]
Zhang, Ling [4 ]
Zhao, Xueya [1 ]
Hou, Yu [1 ]
机构：
[1] Chongqing Med Univ, Biol Sci Inst, Chongqing, Peoples R China
[2] Third Mil Med Univ, Army Med Univ, Clin Hematol, Chongqing, Peoples R China
[3] Chongqing Univ, Sch Med, Chongqing, Peoples R China
[4] Chongqing Med Univ, Sch Lab Med, Key Lab Lab Med Diagnost Designated, Minist Educ, Chongqing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金：
中国国家自然科学基金;
关键词：
leukemic stem cells (LSCs); oxidative phosphorylation (OXPHOS); electron transport chain; tricarboxylic acid cycle (TCA cycle); mitochondria; METABOLIC VULNERABILITY; THERAPEUTIC STRATEGY; SELF-RENEWAL; COMPLEX I; INHIBITION; CANCER; RESISTANCE; CYCLE; RESPIRATION; VENETOCLAX;
D O I：
10.3389/fonc.2022.899502
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by multiple cytogenetic and molecular abnormalities, with a very poor prognosis. Current treatments for AML often fail to eliminate leukemic stem cells (LSCs), which perpetuate the disease. LSCs exhibit a unique metabolic profile, especially dependent on oxidative phosphorylation (OXPHOS) for energy production. Whereas, normal hematopoietic stem cells (HSCs) and leukemic blasts rely on glycolysis for adenosine triphosphate (ATP) production. Thus, understanding the regulation of OXPHOS in LSCs may offer effective targets for developing clinical therapies in AML. This review summarizes these studies with a focus on the regulation of the electron transport chain (ETC) and tricarboxylic acid (TCA) cycle in OXPHOS and discusses potential therapies for eliminating LSCs.
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页数：9
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