Prognostic Value of Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

被引：35

作者：

Shen, Haixiang ^{[1
]}

Liu, Jin ^{[2
]}

Chen, Shiming ^{[1
]}

Ma, Xueyou ^{[1
]}

Ying, Yufan ^{[1
]}

Li, Jiangfeng ^{[1
]}

Wang, Weiyu ^{[1
]}

Wang, Xiao ^{[1
]}

Xie, Liping ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Urol, Affiliated Hosp 1, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Surg Oncol, Hangzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

tumor-associated macrophages; clinicopathological significance; survival; clear cell renal cell carcinoma; biomarker; CANCER; HEAD; POLARIZATION; INFLAMMATION; ACTIVATION; EXPRESSION; M1;

D O I：

10.3389/fonc.2021.657318

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Tumor-associated macrophages (TAMs) are the major immune cells in tumor microenvironment. The prognostic significance of TAMs has been confirmed in various tumors. However, whether TAMs can be prognostic factors in clear cell renal cell carcinoma (ccRCC) is unclear. In this study, we aimed to clarify the prognostic value of TAMs in ccRCC. Methods We searched PubMed, Embase, and the Web of Science for relevant published studies before December 19, 2020. Evidence from enrolled studies were pooled and analyzed by a meta-analysis. Hazard ratios (HRs) and odd ratios (ORs) with 95% confidence intervals (CIs) were computed to evaluate the pooled results. Results Both of high CD68+ TAMs and M2-TAMs were risk factors for poor prognosis in ccRCC patients. The pooled HRs indicated that elevated CD68+ TAMs correlated with poor OS and PFS (HR: 3.97, 95% CI 1.39-11.39; HR: 5.73, 95% CI 2.36-13.90, respectively). For M2-TAMs, the pooled results showed ccRCC patients with high M2-TAMs suffered a worse OS and shorter PFS, with HR 1.32 (95% CI 1.16-1.50) and 1.40 (95% CI 1.14-1.72), respectively. Also, high density of TAMs was associated with advanced clinicopathological features in ccRCC. Conclusions TAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC. Further researches are warranted to validate our results.

引用

页数：11

共 63 条

[1] Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses [J].

Aggen, David H. ;

Ager, Casey R. ;

Obradovic, Aleksandar Z. ;

Chowdhury, Nivedita ;

Ghasemzadeh, Ali ;

Mao, Wendy ;

Chaimowitz, Matthew G. ;

Lopez-Bujanda, Zoila A. ;

Spina, Catherine S. ;

Hawley, Jessica E. ;

Dallos, Matthew C. ;

Zhang, Cheng ;

Wang, Vinson ;

Li, Hu ;

Guo, Xinzheng, V ;

Drake, Charles G. .

CLINICAL CANCER RESEARCH, 2021, 27 (02) :608-621

[2] Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC [J].

Almatroodi, S. A. ;

McDonald, C. F. ;

Darby, I. A. ;

Pouniotis, D. S. .

CANCER MICROENVIRONMENT, 2016, 9 (01) :1-11

[3] CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans [J].

Beatty, Gregory L. ;

Chiorean, Elena G. ;

Fishman, Matthew P. ;

Saboury, Babak ;

Teitelbaum, Ursina R. ;

Sun, Weijing ;

Huhn, Richard D. ;

Song, Wenru ;

Li, Dongguang ;

Sharp, Leslie L. ;

Torigian, Drew A. ;

O'Dwyer, Peter J. ;

Vonderheide, Robert H. .

SCIENCE, 2011, 331 (6024) :1612-1616

[4] Understanding the tumor immune microenvironment (TIME) for effective therapy [J].

Binnewies, Mikhail ;

Roberts, Edward W. ;

Kersten, Kelly ;

Chan, Vincent ;

Fearon, Douglas F. ;

Merad, Miriam ;

Coussens, Lisa M. ;

Gabrilovich, Dmitry I. ;

Ostrand-Rosenberg, Suzanne ;

Hedrick, Catherine C. ;

Vonderheide, Robert H. ;

Pittet, Mikael J. ;

Jain, Rakesh K. ;

Zou, Weiping ;

Howcroft, T. Kevin ;

Woodhouse, Elisa C. ;

Weinberg, Robert A. ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (05) :541-550

[5] Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].

Biswas, Subhra K. ;

Mantovani, Alberto .

NATURE IMMUNOLOGY, 2010, 11 (10) :889-896

[6]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[7] Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment [J].

Chanmee, Theerawut ;

Ontong, Pawared ;

Konno, Kenjiro ;

Itano, Naoki .

CANCERS, 2014, 6 (03) :1670-1690

[8] Targeting tumor-associated macrophages as an antitumor strategy [J].

Cheng, Nan ;

Bai, Xuexia ;

Shu, Yuxin ;

Ahmad, Owais ;

Shen, Pingping .

BIOCHEMICAL PHARMACOLOGY, 2021, 183

[9] Functional polarization of tumour-associated macrophages by tumour-derived lactic acid [J].

Colegio, Oscar R. ;

Ngoc-Quynh Chu ;

Szabo, Alison L. ;

Chu, Thach ;

Rhebergen, Anne Marie ;

Jairam, Vikram ;

Cyrus, Nika ;

Brokowski, Carolyn E. ;

Eisenbarth, Stephanie C. ;

Phillips, Gillian M. ;

Cline, Gary W. ;

Phillips, Andrew J. ;

Medzhitov, Ruslan .

NATURE, 2014, 513 (7519) :559-+

[10] Inflammation and cancer [J].

Coussens, LM ;

Werb, Z .

NATURE, 2002, 420 (6917) :860-867

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