RETRACTED: Human telomeric G-quadruplex: targeting with small molecules (Retraction of vol 6, pg 627, 2008) (Retracted Article)

被引：15

作者：

Arora, Amit ^{[1
]}

Kumar, Niti ^{[1
]}

Agarwal, Tani ^{[1
]}

Maiti, Souvik ^{[1
]}

机构：

[1] CSIR, Inst Genom & Integrat Biol, Prote & Struct Biol Unit, Delhi 110007, India

来源：

FEBS JOURNAL | 2010年 / 277卷 / 05期

关键词：

alkaloids; anticancer agent; click chemistry; ethidium derivative; G-quadruplex; human telomere; metallo-organic complex; N-methylated ligands; proto-oncogenes; telomerase; HIGHLY SELECTIVE LIGANDS; DNA-DAMAGE RESPONSE; C-MYC; IN-VITRO; INTERACTIVE AGENTS; STABILIZING LIGANDS; PROMOTER REGION; MACROCYCLIC HEXAOXAZOLE; QUINDOLINE DERIVATIVES; POTENTIAL INHIBITORS;

D O I：

10.1111/j.1742-4658.2009.07461.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past few decades, numerous small molecules have been designed to specifically and selectively target the unusual secondary structure in DNA called the G-quadruplex. Because these ligands have been shown to selectively inhibit the growth of cancer cells, they have become a central focus for the development of novel anticancer agents. However, there are many challenges which demand greater effort in order to devise strategies for rational drug design with utmost selectivity. This minireview aims to reflect recent developments in the design of G-quadruplex ligands and also discusses the future outlook for designing more effective G-quadruplex interacting ligands.

引用

页码：1345 / +

页数：16

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