Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression

被引：108

作者：

Wang, Lina ^{[1
]}

Zhang, Xiangjian ^{[1
]}

Liu, Lingling ^{[1
]}

Yang, Rui ^{[1
]}

Cui, Lili ^{[1
]}

Li, Min ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2010年 / 471卷 / 03期

关键词：

Cerebral ischemia; High-mobility group box 1; Atorvastatin; Neuroprotection; CEREBRAL-ARTERY OCCLUSION; STROKE; ACTIVATION;

D O I：

10.1016/j.neulet.2010.01.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammatory processes play a key, mainly detrimental role in the pathophysiology of ischemic stroke. Currently, HMGB1-induced NF-kappa B activation pathway has been recognized as a key contributor to the proinflammatory response. It has been proved that chronic administration and pre-treatment with statins could protect brain tissue against ischemic injury. However, little is known about the effects of statins in the acute phase after cerebral ischemia. Thus, this study investigated the atorvastatin's protective role and the underlying mechanisms in cerebral ischemia. After middle cerebral artery occlusion (MCAO), atorvastatin was administered immediately. WE found that atorvastatin dramatically improved neurological deficits, reduced brain water contents and infarct sizes at 24 h after stroke. Moreover, the over-expression of HMGB1, TLR4 and NF-kappa B induced by ischemia was significantly attenuated by atorvastatin. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：152 / 156

页数：5

共 27 条

[11] Ischemic cell death in brain neurons [J].

Lipton, P .

PHYSIOLOGICAL REVIEWS, 1999, 79 (04) :1431-1568

[12] Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF-κB expression [J].

Liu, Ying ;

Zhang, Xiang-jian ;

Yang, Chen-hui ;

Fan, Hong-guang .

BRAIN RESEARCH, 2009, 1268 :174-180

[13] Mechanisms, challenges and opportunities in stroke [J].

Lo, EH ;

Dalkara, T ;

Moskowitz, MA .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (05) :399-415

[14] REVERSIBLE MIDDLE CEREBRAL-ARTERY OCCLUSION WITHOUT CRANIECTOMY IN RATS [J].

LONGA, EZ ;

WEINSTEIN, PR ;

CARLSON, S ;

CUMMINS, R .

STROKE, 1989, 20 (01) :84-91

[15] High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal [J].

Lotze, MT ;

Tracey, KJ .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (04) :331-342

[16]

Malek R, 2007, PHARMACOL REP, V59, P25

[17] Favorable outcome of ischemic stroke in patients pretreated with statins [J].

Martí-Fábregas, J ;

Gomis, M ;

Arboix, A ;

Aleu, A ;

Pagonabarraga, J ;

Belvís, R ;

Cocho, D ;

Roquer, J ;

Rodríguez, A ;

García, MD ;

Molina-Porcel, L ;

Díaz-Manera, J ;

Mart-Vilalta, JL .

STROKE, 2004, 35 (05) :1117-1121

[18]

MCGIRT MJ, 2002, STROKE, V33, P2256

[19] High mobility group box 1 protein interacts with multiple Toll-like receptors [J].

Park, JS ;

Gamboni-Robertson, F ;

He, QB ;

Svetkauskaite, D ;

Kim, JY ;

Strassheim, D ;

Sohn, JW ;

Yamada, S ;

Maruyama, I ;

Banerjee, A ;

Ishizaka, A ;

Abraham, E .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2006, 290 (03) :C917-C924

[20] Release of chromatin protein HMGB1 by necrotic cells triggers inflammation [J].

Scaffidi, P ;

Misteli, T ;

Bianchi, ME .

NATURE, 2002, 418 (6894) :191-195

← 1 2 3 →