DROSOPHILA MELANOGASTER SHOW A THRESHOLD EFFECT IN RESPONSE TO RADIATION

被引：8

作者：

Antosh, Michael ^{[1
]}

Fox, David ^{[1
]}

Hasselbacher, Thomas ^{[1
]}

Lanou, Robert ^{[2
]}

Neretti, Nicola ^{[1
,3
]}

Cooper, Leon N. ^{[1
,2
]}

机构：

[1] Brown Univ, Inst Brain & Neural Syst, Providence, RI 02912 USA

[2] Brown Univ, Dept Phys, Providence, RI 02912 USA

[3] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

来源：

DOSE-RESPONSE | 2014年 / 12卷 / 04期

关键词：

low dose radiation; gene expression; Drosophila melanogaster; threshold effect; X-IRRADIATION; MUTATION FREQUENCY; LIFE-SPAN; BIOCONDUCTOR; LONGEVITY; STRESS; AGE; INTEGRATION; REDUCTION; PACKAGE;

D O I：

10.2203/dose-response.13-047.Antosh

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.

引用

页码：551 / 581

页数：31

共 54 条

[1] Differential expression analysis for sequence count data [J].

Anders, Simon ;

Huber, Wolfgang .

GENOME BIOLOGY, 2010, 11 (10)

[2] Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury [J].

Azzam, Edouard I. ;

Jay-Gerin, Jean-Paul ;

Pain, Debkumar .

CANCER LETTERS, 2012, 327 (1-2) :48-60

[3] Rearing in different light regimes affects courtship behaviour in Drosophila melanogaster [J].

Barth, M ;

Hirsch, HVB ;

Heisenberg, M .

ANIMAL BEHAVIOUR, 1997, 53 :25-38

[4] Reactive oxygen species: Destroyers or messengers? [J].

Bartosz, Grzegorz .

BIOCHEMICAL PHARMACOLOGY, 2009, 77 (08) :1303-1315

[5] Comparative transcriptional profiling identifies takeout as a gene that regulates life span [J].

Bauer, Johannes ;

Antosh, Michael ;

Chang, Chengyi ;

Schorl, Christoph ;

Kolli, Santharam ;

Neretti, Nicola ;

Helfand, Stephen L. .

AGING-US, 2010, 2 (05) :298-310

[6] AGE OF DEATH IN DROSOPHILA FOLLOWING SUBLETHAL EXPOSURE TO GAMMA RADIATION [J].

BAXTER, RC ;

BLAIR, HA .

RADIATION RESEARCH, 1967, 31 (02) :287-&

[7] KINETICS OF AGING AS REVEALED BY X-RAY-DOSE-LETHALITY RELATIONS IN DROSOPHILA [J].

BAXTER, RC ;

BLAIR, HA .

RADIATION RESEARCH, 1967, 30 (01) :48-&

[8] The role of oxidative damage and stress in aging [J].

Bokov, A ;

Chaudhuri, A ;

Richardson, A .

MECHANISMS OF AGEING AND DEVELOPMENT, 2004, 125 (10-11) :811-826

[9]

Bokov A.F., 2012, SURVOMATIC ANAL LONG

[10] Reactive oxygen species and peroxisomes: Struggling for balance [J].

Bonekamp, Nina A. ;

Voelkl, Alfred ;

Fahimi, H. Dariush ;

Schrader, Michael .

BIOFACTORS, 2009, 35 (04) :346-355

← 1 2 3 4 5 6 →