Mast cells as therapeutic target in cancer

被引：60

作者：

Ribatti, Domenico ^{[1
,2
]}

机构：

[1] Univ Bari, Sch Med, Dept Basic Med Sci Neurosci & Sensory Organs, Policlin Piazza G Cesare 11, I-70124 Bari, Italy

[2] Natl Canc Inst Giovanni Paolo II, Bari, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 778卷

关键词：

Anticancer agents; Mast cells; Tryptase; Tumor growth; Tyrosine kinase inhibitors; TYROSINE KINASE INHIBITOR; BONE-MARROW ANGIOGENESIS; CHRONIC LYMPHOCYTIC-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; HUMAN-BREAST-CANCER; CHORIOALLANTOIC MEMBRANE; SYSTEMIC MASTOCYTOSIS; TUMOR ANGIOGENESIS; TRYPTASE ACTIVITY; PULMONARY ADENOCARCINOMA;

D O I：

10.1016/j.ejphar.2015.02.056

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor -promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell -mediated immune suppression. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：152 / 157

页数：6

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