Mast cells as therapeutic target in cancer

被引：61
作者：
Ribatti, Domenico [1 ,2 ]
机构：
[1] Univ Bari, Sch Med, Dept Basic Med Sci Neurosci & Sensory Organs, Policlin Piazza G Cesare 11, I-70124 Bari, Italy
[2] Natl Canc Inst Giovanni Paolo II, Bari, Italy
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 778卷
关键词：
Anticancer agents; Mast cells; Tryptase; Tumor growth; Tyrosine kinase inhibitors; TYROSINE KINASE INHIBITOR; BONE-MARROW ANGIOGENESIS; CHRONIC LYMPHOCYTIC-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; HUMAN-BREAST-CANCER; CHORIOALLANTOIC MEMBRANE; SYSTEMIC MASTOCYTOSIS; TUMOR ANGIOGENESIS; TRYPTASE ACTIVITY; PULMONARY ADENOCARCINOMA;
D O I：
10.1016/j.ejphar.2015.02.056
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor -promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell -mediated immune suppression. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：152 / 157
页数：6
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