Brain-heart interactions: physiology and clinical implications

被引:213
作者
Silvani, Alessandro [1 ]
Calandra-Buonaura, Giovanna [2 ,3 ]
Dampney, Roger A. L. [4 ,5 ]
Cortelli, Pietro [2 ,3 ]
机构
[1] Univ Bologna, PRISM Lab, Dept Biomed & Neuromotor Sci, Bologna, Italy
[2] Univ Bologna, Dept Biomed & Neuromotor Sci, Auton Unit, Bologna, Italy
[3] Bellaria Univ Hosp, Inst Neurol Sci Bologna, IRCCS, Block G,Via Altura 3, I-40139 Bologna, Italy
[4] Univ Sydney, Sch Med Sci Physiol, Sydney, NSW, Australia
[5] Univ Sydney, Bosch Inst Biomed Res, Sydney, NSW, Australia
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2016年 / 374卷 / 2067期
关键词
brain-heart interactions; autonomic nervous system; physiology; human disease; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; RESPIRATORY SINUS ARRHYTHMIA; SYMPATHETIC-NERVE ACTIVITY; CENTRAL AUTONOMIC COMMANDS; BLOOD-PRESSURE; CENTRAL MECHANISMS; SLEEP-DEPRIVATION; AGRYPNIA EXCITATA; FUNCTIONAL-ORGANIZATION; CARDIOVASCULAR CONTROL;
D O I
10.1098/rsta.2015.0181
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The brain controls the heart directly through the sympathetic and parasympathetic branches of the autonomic nervous system, which consists of multi-synaptic pathways from myocardial cells back to peripheral ganglionic neurons and further to central preganglionic and premotor neurons. Cardiac function can be profoundly altered by the reflex activation of cardiac autonomic nerves in response to inputs from baro-, chemo-, nasopharyngeal and other receptors as well as by central autonomic commands, including those associated with stress, physical activity, arousal and sleep. In the clinical setting, slowly progressive autonomic failure frequently results from neurodegenerative disorders, whereas autonomic hyperactivity may result from vascular, inflammatory or traumatic lesions of the autonomic nervous system, adverse effects of drugs and chronic neurological disorders. Both acute and chronic manifestations of an imbalanced brain-heart interaction have a negative impact on health. Simple, widely available and reliable cardiovascular markers of the sympathetic tone and of the sympathetic-parasympathetic balance are lacking. A deeper understanding of the connections between autonomic cardiac control and brain dynamics through advanced signal and neuroimage processing may lead to invaluable tools for the early detection and treatment of pathological changes in the brain-heart interaction.
引用
收藏
页数:22
相关论文
共 152 条
[1]   DIFFERENTIAL SYMPATHETIC REGULATION OF AUTOMATIC, CONDUCTILE, AND CONTRACTILE TISSUE IN DOG HEART [J].
ARDELL, JL ;
RANDALL, WC ;
CANNON, WJ ;
SCHMACHT, DC ;
TASDEMIROGLU, E .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :H1050-H1059
[2]   Potential clinical relevance of the 'little brain' on the mammalian heart [J].
Armour, J. A. .
EXPERIMENTAL PHYSIOLOGY, 2008, 93 (02) :165-176
[3]   A critical review of the pathophysiology of dysautonomia following traumatic brain injury [J].
Baguley, Ian J. ;
Heriseanu, Roxana E. ;
Cameron, Ian D. ;
Nott, Melissa T. ;
Slewa-Younan, Shameran .
NEUROCRITICAL CARE, 2008, 8 (02) :293-300
[4]   The excitatory:inhibitory ratio model (EIR model):: An integrative explanation of acute autonomic overactivity syndromes [J].
Baguley, Ian J. .
MEDICAL HYPOTHESES, 2008, 70 (01) :26-35
[5]   Central circuits mediating patterned autonomic activity during active vs. passive emotional coping [J].
Bandler, R ;
Keay, KA ;
Floyd, N ;
Price, J .
BRAIN RESEARCH BULLETIN, 2000, 53 (01) :95-104
[6]   Mice Show Circadian Rhythms of Blood Pressure During Each Wake-Sleep State [J].
Bastianini, Stefano ;
Silvani, Alessandro ;
Berteotti, Chiara ;
Lo Martire, Viviana ;
Zoccoli, Giovanna .
CHRONOBIOLOGY INTERNATIONAL, 2012, 29 (01) :82-86
[7]  
BAUST W, 1969, EXP BRAIN RES, V7, P169
[8]   Posterior reversible encephalopathy syndrome as a complication of Guillain-Barre syndrome [J].
Bavikatte, G. ;
Gaber, Tarek ;
Eshiett, M. U. -A. .
JOURNAL OF CLINICAL NEUROSCIENCE, 2010, 17 (07) :924-926
[9]   THE CENTRAL AUTONOMIC NETWORK - FUNCTIONAL-ORGANIZATION, DYSFUNCTION, AND PERSPECTIVE [J].
BENARROCH, EE .
MAYO CLINIC PROCEEDINGS, 1993, 68 (10) :988-1001
[10]  
Benarroch EE., 2014, AUTONOMIC NEUROLOGY, P170