Structure and function of lipid rafts

被引：0
|
作者：
Chen, L [1 ]
Xu, CM [1 ]
Yuan, JG [1 ]
Pan, HZ [1 ]
机构：
[1] Chinese Acad Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Peking Union Med Coll, Beijing 100005, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 30卷 / 01期
关键词：
lipid raft; caveolae; caveolin; signal transduction; GPI-anchored protein;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane. Caveolae, a type of lipid rafts, is characterized by high levels of cholesterol, sphingolipids and proteins, and is identified by the presence of the protein caveolin. The structure and component of lipid rafts is used of reciprocity and comformational change between proteins. Lipid rafts are associated with signal transduction and cellar proteins movement. The disfunction of lipid rafts is related to some diseases such as infection, heart disease, cancer, muscular dystrophy and prion protein diseases.
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收藏
页码：54 / 59
页数：6
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