Homeodomain proteins in action: similar DNA binding preferences, highly variable connectivity

被引：40

作者：

Bobola, Nicoletta ^{[1
]}

Merabet, Samir ^{[2
]}

机构：

[1] Univ Manchester, Sch Med Sci, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England

[2] Ecole Normale Super Lyon, CNRS, Inst Genom Fonct Lyon, Lyon, France

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2017年 / 43卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

TRANSCRIPTION FACTOR-BINDING; LONG NONCODING RNAS; HOX PROTEINS; INTRINSIC DISORDER; CELL FATE; SPECIFICITY; COMPLEX; GENOME; RECOGNITION; MECHANISMS;

D O I：

10.1016/j.gde.2016.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Homeodomain proteins are evolutionary conserved proteins present in the entire eukaryote kingdom. They execute functions that are essential for life, both in developing and adult organisms. Most homeodomain proteins act as transcription factors and bind DNA to control the activity of other genes. In contrast to their similar DNA binding specificity, homeodomain proteins execute highly diverse and context-dependent functions. Several factors, including genome accessibility, DNA shape, combinatorial binding and the ability to interact with many transcriptional partners, diversify the activity of homeodomain proteins and culminate in the activation of highly dynamic, context-specific transcriptional programs. Clarifying how homeodomain transcription factors work is central to our understanding of development, disease and evolution.

引用

页码：1 / 8

页数：8

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