An unusual case of enoxaparin induced thrombocytopenia in intensive care unit

被引：0

作者：

Giuliani, Enrico ^{[1
]}

Melegari, Gabriele ^{[1
]}

Farinetti, Alberto ^{[2
]}

Barbieri, Alberto ^{[1
]}

Mattioli, Anna Vittoria ^{[3
]}

机构：

[1] Univ Modena & Reggio Emilia, Intens Care Unit, Dept Anesthesiol, I-41124 Modena, Italy

[2] Univ Modena & Reggio Emilia, Intens Care Unit, Dept Surg, I-41124 Modena, Italy

[3] Univ Modena & Reggio Emilia, Intens Care Unit, Dept Life Sci, I-41124 Modena, Italy

来源：

ANNALI ITALIANI DI CHIRURGIA | 2015年 / 86卷 / 06期

关键词：

Enoxaparin; Heparin induced thrombocytopenia; Thrombocytopenia; HEPARIN-INDUCED THROMBOCYTOPENIA; MOLECULAR-WEIGHT HEPARIN; PROGNOSTIC-SIGNIFICANCE; RISK;

D O I：

暂无

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

OBJECTIVES: To present a case of heparin induced thrombocytopenia in a patient treated with enoxaparin. METHODS: A case of heparin-induced thrombocytopenia was examinated with a detailed platelet count analysis over the time and with detection of platelets antibodies. RESULTS: The detection of platelet antobodies and the recovery of platelet count after cessation of enoxaparin strongly support the diagnosis of heparin-induced thrombocytopenia (HIT). CONCLUSION: HIT is a severe side effects of heparin administration. It is more frequent in patients treated with unfractionated heparin however can also be induced by low molecular weight heparin. Guideline suggests the cessation of heparin administration and the treatment of patients with fondaparinux.

引用

页码：545 / 547

页数：3

共 16 条

[1] Thrombocytopenia in Patients With an Acute Coronary Syndrome (from the Global Registry of Acute Coronary Events [GRACE]) [J].

Gore, Joel M. ;

Spencer, Frederick A. ;

Gurfinkel, Enrique P. ;

Lopez-Sendon, Jose ;

Steg, Gabriel ;

Granger, Christopher B. ;

FitzGerald, Gordon ;

Agnelli, Giancarlo .

AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (02) :175-180

[2] Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis [J].

Greinacher, A ;

Farner, B ;

Kroll, H ;

Kohlmann, T ;

Warkentin, TE ;

Eichler, P .

THROMBOSIS AND HAEMOSTASIS, 2005, 94 (01) :132-135

[3] Contribution of Bleeding and Thromboembolic Events to In-Hospital Mortality Among Patients With Thrombocytopenia Treated With Heparin [J].

Jolicoeur, E. Marc ;

Ohman, E. Magnus ;

Honeycutt, Emily ;

Becker, Richard C. ;

Crespo, Eric M. ;

Oliveira, Gustavo B. F. ;

Moliterno, David J. ;

Anstrom, Kevin J. ;

Granger, Christopher B. .

AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (02) :292-297

[4] Emergency Department Awareness of Heparin-Induced Thrombocytopenia: How Frequently Is Risk Assessment Documented in Patients With Thrombosis? [J].

Levine, Robert L. ;

Funk, Robert ;

Hergenroeder, Georgene W. ;

Hursting, Marcie J. .

AMERICAN JOURNAL OF MEDICAL QUALITY, 2010, 25 (05) :365-369

[5] Treatment and Prevention of Heparin-Induced Thrombocytopenia Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Linkins, Lori-Ann ;

Dans, Antonio L. ;

Moores, Lisa K. ;

Bona, Robert ;

Davidson, Bruce L. ;

Schulman, Sam ;

Crowther, Mark .

CHEST, 2012, 141 (02) :E495S-E530S

[6] Risk for heparin-induced thrombocytopenia. with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis [J].

Martel, N ;

Lee, J ;

Wells, PS .

BLOOD, 2005, 106 (08) :2710-2715

[7] Thrombotic events in patients with antiplatelet factor 4/heparin antibodies [J].

Mattioli, A. V. ;

Bonetti, L. ;

Carletti, U. ;

Ambrosio, G. ;

Mattioli, G. .

HEART, 2009, 95 (16) :1350-1354

[8] Heparin/PF4 antibodies formation after heparin treatment: Temporal aspects and long-term follow-up [J].

Mattioli, Anna Vittoria ;

Bonetti, Lorenzo ;

Zennaro, Mauro ;

Ambrosio, Giuseppe ;

Mattioli, Giorgio .

AMERICAN HEART JOURNAL, 2009, 157 (03) :589-595

[9]

Mattioli AV, 2014, HEPARIN INDUCED THRO

[10] No difference in risk for thrombocytopenia during treatment of pulmonary embolism and deep venous thrombosis with either low-molecular-weight heparin or unfractionated heparin - A metaanalysis [J].

Morris, Timothy A. ;

Castrejon, Selene ;

Devendra, Gehan ;

Gamst, Anthony C. .

CHEST, 2007, 132 (04) :1131-1139

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