Relationship between whole blood serotonin and repetitive behaviors in autism

被引：30

作者：

Kolevzon, Alexander ^{[1
,2
]}

Newcorn, Jeffrey H. ^{[1
]}

Kryzak, Lauren ^{[2
]}

Chaplin, William ^{[3
]}

Watner, Dryden ^{[3
]}

Hollander, Eric ^{[1
,2
,6
]}

Smith, Christopher J. ^{[4
]}

Cook, Edwin H., Jr. ^{[5
]}

Silverman, Jeremy M. ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA

[3] St Johns Univ, Dept Psychol, New York, NY USA

[4] SW Autism Res & Resource Ctr, Phoenix, AZ USA

[5] Univ Illinois, Dept Psychiat, Inst Juvenile Res, Chicago, IL 60612 USA

[6] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Psychiat, Bronx, NY USA

来源：

PSYCHIATRY RESEARCH | 2010年 / 175卷 / 03期

关键词：

Autism; Serotonin; Repetitive behavior; Self-injury; Aggression; PERVASIVE DEVELOPMENTAL DISORDERS; PLATELET SEROTONIN; MENTAL-RETARDATION; CHILDREN; RELATIVES;

D O I：

10.1016/j.psychres.2009.02.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study was conducted to examine the relationship between whole blood serotonin level and behavioral symptoms in 78 subjects with autism. No significant associations were found between serotonin level and the primary behavioral outcome measures. However. a significant inverse relationship between serotonin level and self-injury was demonstrated. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：274 / 276

页数：3

共 16 条

[1] Varieties of repetitive behavior in autism: Comparisons to mental retardation [J].

Bodfish, JW ;

Symons, FJ ;

Parker, DE ;

Lewis, MH .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2000, 30 (03) :237-243

[2] Role of altered brain serotonin mechanisms in autism [J].

Chugani, DC .

MOLECULAR PSYCHIATRY, 2002, 7 (Suppl 2) :S16-S17

[3]

Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO

[4]

2-9

[5]

Cook E H Jr, 1990, J Neuropsychiatry Clin Neurosci, V2, P268

[6] PLATELET SEROTONIN STUDIES IN HYPERSEROTONEMIC RELATIVES OF CHILDREN WITH AUTISTIC DISORDER [J].

COOK, EH ;

ARORA, RC ;

ANDERSON, GM ;

BERRYKRAVIS, EM ;

YAN, SY ;

YEOH, HC ;

SKLENA, PJ ;

CHARAK, DA ;

LEVENTHAL, BL .

LIFE SCIENCES, 1993, 52 (25) :2005-2015

[7] Platelet serotonin content correlates inversely with life history of aggression in personality-disordered subjects [J].

Goveas, JS ;

Csernansky, JG ;

Coccaro, EF .

PSYCHIATRY RESEARCH, 2004, 126 (01) :23-32

[8] Hyperserotonemia in adults with autistic disorder [J].

Hranilovic, Dubravka ;

Bujas-Petkovic, Zorana ;

Vragovic, Renata ;

Vuk, Tomislav ;

Hock, Karlo ;

Jernej, Branimir .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2007, 37 (10) :1934-1940

[9] ASSOCIATION OF SEROTONIN CONCENTRATION TO BEHAVIOR AND IQ IN AUTISTIC-CHILDREN [J].

KUPERMAN, S ;

BEEGHLY, J ;

BURNS, T ;

TSAI, L .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1987, 17 (01) :133-140

[10] SEROTONIN RELATIONSHIPS OF AUTISTIC PROBANDS AND THEIR 1ST-DEGREE RELATIVES [J].

KUPERMAN, S ;

BEEGHLY, JHL ;

BURNS, TL ;

TSAI, LY .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1985, 24 (02) :186-190

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