Natural products chemistry: The emerging trends and prospective goals

被引:84
作者
Khan, Riaz A. [1 ,2 ]
机构
[1] Qassim Univ, Dept Med Chem, Qasim 51452, Saudi Arabia
[2] Manav Rachna Int Univ, Natl Capital Reg, Faridabad 121004, HR, India
关键词
Emerging trends; Natural products chemistry; Perspective; Prospects; CRYPTIC POLYKETIDE METABOLITES; DRUG DISCOVERY; GENE-CLUSTER; BIOSYNTHETIC PATHWAYS; BACTERIAL SYMBIONT; CYANOBACTERIAL SYMBIONT; COMBINATORIAL CHEMISTRY; HETEROLOGOUS EXPRESSION; FUNCTIONAL-ANALYSIS; CHEMICAL DEFENSE;
D O I
10.1016/j.jsps.2018.02.015
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The role and contributions of natural products chemistry in advancements of the physical and biological sciences, its interdisciplinary domains, and emerging of new avenues by providing novel applications, constructive inputs, thrust, comprehensive understanding, broad perspective, and a new vision for future is outlined. The developmental prospects in bio-medical, health, nutrition, and other interrelated sciences along with some of the emerging trends in the subject area are also discussed as part of the current review of the basic and core developments, innovation in techniques, advances in methodology, and possible applications with their effects on the sciences in general and natural products chemistry in particular. The overview of the progress and ongoing developments in broader areas of the natural products chemistry discipline, its role and concurrent economic and scientific implications, contemporary objectives, future prospects as well as impending goals are also outlined. A look at the natural products chemistry in providing scientific progress in various disciplines is deliberated upon. (C) 2018 The Author. Production and hosting by Elsevier B. V. on behalf of King Saud University.
引用
收藏
页码:739 / 753
页数:15
相关论文
共 262 条
[81]   HTS and hit finding in academia - from chemical genomics to drug discovery [J].
Frearson, Julie A. ;
Collie, Iain T. .
DRUG DISCOVERY TODAY, 2009, 14 (23-24) :1150-1158
[82]   Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides [J].
Freeman, Michael F. ;
Gurgui, Cristian ;
Helf, Maximilian J. ;
Morinaka, Brandon I. ;
Uria, Agustinus R. ;
Oldham, Neil J. ;
Sahl, Hans-Georg ;
Matsunaga, Shigeki ;
Piel, Joern .
SCIENCE, 2012, 338 (6105) :387-390
[83]   The discovery of antibacterial agents using diversity-oriented synthesis [J].
Galloway, Warren R. J. D. ;
Bender, Andreas ;
Welch, Martin ;
Spring, David R. .
CHEMICAL COMMUNICATIONS, 2009, (18) :2446-2462
[84]  
Garson MJ, 2001, CRC MAR SCI, P71
[85]   Functional Analysis of Environmental DNA-Derived Microviridins Provides New Insights into the Diversity of the Tricyclic Peptide Family [J].
Gatte-Picchi, Douglas ;
Weiz, Annika ;
Ishida, Keishi ;
Hertweck, Christian ;
Dittmann, Elke .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 80 (04) :1380-1387
[86]   The re-emerging role of microbial natural products in antibiotic discovery [J].
Genilloud, Olga .
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2014, 106 (01) :173-188
[87]   Synthetic libraries of tyrosine-derived bacterial metabolites [J].
Georgiades, Savvas N. ;
Clardy, Jon .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (10) :3117-3121
[88]  
Gilbert H.J., 1999, RECENT ADV CARBOHYDR, P302
[89]   Synthesis and biological activities of marine terpene-adenine hybrids and synthetic analogs [J].
Gundersen, Lise-Lotte .
PHYTOCHEMISTRY REVIEWS, 2013, 12 (03) :467-486
[90]  
Hagino N, 2000, Rinsho Byori, V48, P764