Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia

被引:7
作者
Milone, Jorge H. [1 ]
Enrico, Alicia [1 ]
机构
[1] Hosp Italiano La Plata, Bone Marrow Transplantat Unit, La Plata, Buenos Aires, Argentina
关键词
ALL; Philadelphia chromosome; tyrosine kinase inhibitors; STEM-CELL TRANSPLANTATION; BONE-MARROW; ADULT PATIENTS; IMATINIB; CHILDREN; CHEMOTHERAPY; MECHANISMS;
D O I
10.3109/10428190903370395
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The presence of the Philadelphia chromosome is a poor prognosis factor in acute lymphoblastic leukemia (ALL), in both children and adults. Using molecular techniques of the gen bcr/abl, it is possible to detect the abnormality, in up to the 40% of adult patients. The unsatisfactory results with conventional chemotherapy schemes have determined the intensification of the treatments and the consideration of allogenic bone marrow transplants as the best therapeutic instance. The development of tyrosine kinase inhibitors have become a therapeutic improvement in the treatment of Philadelphia chromosome-positive ALL, being combined with chemotherapy schemes, only in a selected group of patients, even in therapeutic programs that include transplant.
引用
收藏
页码:9 / 15
页数:7
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