Regioselective Gold-Catalyzed Oxidative C-N Bond Formation

被引：64
|
作者：
Marchetti, Louis [1 ]
Kantak, Abhishek [1 ]
Davis, Riley [1 ]
DeBoef, Brenton [1 ]
机构：
[1] Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 02期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
AMINATION;
D O I：
10.1021/ol5034805
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel protocol for the regioselective intermolecular amination of various arenes has been developed. By using an I(III) oxidant in the presence of a Au(I) catalyst, a direct and novel route for regioselectively accessing a variety of substituted aniline moieties has been achieved with yields as high as 90%. Mechanistic insight suggests that regioselectivity can be predicted based on electrophilic aromatic metalation patterns.
引用
收藏
页码：358 / 361
页数：4
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