Gut microbiome, prebiotics, intestinal permeability and diabetes complications

被引：106

作者：

Snelson, Matthew ^{[1
]}

de Pasquale, Cassandra ^{[1
]}

Ekinci, Elif I. ^{[2
,3
]}

Coughlan, Melinda T. ^{[1
,4
]}

机构：

[1] Monash Univ, Alfred Med Res & Educ Precinct, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia

[2] Austin Hlth, Dept Endocrinol, Heidelberg, Vic, Australia

[3] Univ Melbourne, Melbourne Med Sch, Austin Hlth, Dept Med, Melbourne, Vic, Australia

[4] Baker Heart & Diabet Inst, Melbourne, Vic, Australia

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2021年 / 35卷 / 03期

基金：

英国医学研究理事会;

关键词：

diabetes; diabetic kidney disease; prebiotics; short chain fatty acids; intestinal permeability; GLUCAGON-LIKE PEPTIDE-2; CHAIN FATTY-ACIDS; REGULATORY T-CELLS; RESISTANT STARCH; TIGHT JUNCTION; BARRIER FUNCTION; METABOLIC ENDOTOXEMIA; INSULIN-RESISTANCE; GLYCEMIC CONTROL; PROTEIN-KINASE;

D O I：

10.1016/j.beem.2021.101507

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes is a metabolic condition. The composition of the gut microbiota is altered in diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate. Butyrate is associated with a number of beneficial effects including promoting the integrity of the gastrointestinal barrier. Diabetes may lead to an increase in the permeability of the gut barrier, which is thought to contribute to systemic inflammation and worsen the microvascular complications of diabetes. Prebiotics, non-digestible carbohydrates, are fermented by the colonic microbiota leading to the production of a range of metabolites including SCFAs. Thus, prebiotics represent a dietary approach to increase levels of microbially produced SCFAs and improve intestinal permeability in diabetes. Whether prebiotics can lead to a reduction in the risk of developing diabetes complications in individuals with type 2 diabetes needs to be explored. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：13

共 94 条

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