Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange

被引：77

作者：

Colell, Johannes F. P. ^{[1
]}

Emondts, Meike ^{[2
]}

Logan, Angus W. J. ^{[1
]}

Shen, Kun ^{[1
]}

Bae, Junu ^{[1
]}

Shchepin, Roman V. ^{[3
,4
,5
,6
]}

Ortiz, Gerardo X., Jr. ^{[1
]}

Spannring, Peter ^{[7
]}

Wang, Qiu ^{[1
]}

Malcolmson, Steven J. ^{[1
]}

Chekmenev, Eduard Y. ^{[3
,4
,5
,6
,8
]}

Feiters, Martin C. ^{[7
]}

Rutjes, Floris P. J. T. ^{[7
]}

Blumich, Bernhard ^{[2
]}

Theis, Thomas ^{[1
]}

Warren, Warren S. ^{[1
,9
,10
,11
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

[2] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, Worringerweg 2, D-52072 Aachen, Germany

[3] Vanderbilt Univ, VICC, Vanderbilt Inst Imaging Sci VUIIS, Dept Radiol, Nashville, TN 37232 USA

[4] Vanderbilt Univ, VICC, Vanderbilt Inst Imaging Sci VUIIS, Dept Radiol Sci, Nashville, TN 37232 USA

[5] Vanderbilt Univ, VICC, Vanderbilt Inst Imaging Sci VUIIS, Dept Biomed Engn, Nashville, TN 37232 USA

[6] Vanderbilt Univ, VICC, Vanderbilt Inst Imaging Sci VUIIS, Dept Phys & Astron, Nashville, TN 37232 USA

[7] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

[8] Russian Acad Sci, Moscow, Russia

[9] Duke Univ, Dept Phys, Durham, NC 27707 USA

[10] Duke Univ, Dept Radiol, Durham, NC 27707 USA

[11] Duke Univ, Dept Biomed Engn, Durham, NC 27707 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 23期

基金：

美国国家科学基金会;

关键词：

MAGNETIZATION-TRANSFER; SIGNAL AMPLIFICATION; NMR; POLARIZATION; SABRE; COMPLEXES; HYDROGEN; SENSITIVITY; SOLUBILITY; BIOMARKER;

D O I：

10.1021/jacs.7b00569

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived H-1-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure H2O or D2O solutions, on substrates that could not be hyperpolarized in traditional H-1-SABRE experiments, and we record N-15 T-1 relaxation times of up to 2 min.

引用

页码：7761 / 7767

页数：7

共 61 条

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Abragam A., 1983, The Principles of Nuclear Magnetism

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