The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT

被引：10

作者：

Bakhtiar, Shahrzad ^{[1
]}

Shadur, Bella ^{[2
,3
,4
]}

Stepensky, Polina ^{[2
]}

机构：

[1] Univ Hosp Frankfurt, Div Pediat Stem Cell Transplantat & Immunol, Frankfurt, Germany

[2] Hadassah Med Ctr, Dept Bone Marrow Transplantat & Canc Immunotherap, Jerusalem, Israel

[3] Garvan Inst Med Res, Dept Immunol, Darlinghurst, NSW, Australia

[4] Univ New South Wales, Grad Res Sch, Kensington, NSW, Australia

来源：

FRONTIERS IN PEDIATRICS | 2019年 / 7卷

关键词：

neutrophils; neutropenia; leukemia; granulocyte colony-stimulating factor; hematopoietic stem cell transplantation; BONE-MARROW-TRANSPLANTATION; IMMUNODEFICIENCY SYNDROME; HAX1; MUTATIONS; DEFICIENCY; DISEASE; GENE; CLASSIFICATION; BLOOD; ABNORMALITIES; COMPLICATIONS;

D O I：

10.3389/fped.2019.00436

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.

引用

页数：9

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