MS222 does not induce primary DNA damage in fish

被引：27
作者：
Barreto, R. E.
Gontijo, A. M. M. C.
Alves-de-Lima, R. O.
Raymundi, V. C.
Pinhal, D.
Reyes, V. A. V.
Volpato, G. L.
Salvadori, D. M. F.
机构：
[1] UNSEP, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
[2] Inst Pasteur, Unit Biol Interact Hote Parasite, Paris, France
[3] UNSEP, TOXICAN, BR-18618000 Botucatu, SP, Brazil
来源：
AQUACULTURE INTERNATIONAL | 2007年 / 15卷 / 02期
关键词：
anaesthetic tricaine (ethyl meta-aminobenzoate); DNA damage; methanesulfonate salt; MS222; single cell gel (SCG)/Comet assay; stressful practices in aquaculture;
D O I：
10.1007/s10499-007-9073-6
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
The genotoxicity of the anaesthetic MS222 (tricaine) was analysed in fish under both in vivo and in vitro conditions. Based on results of the single cell gel/Comet assay, MS222 had no direct genotoxic effect on the experimental fish, indicating that MS222 does not induce primary DNA damage. These results suggest that the use of this important anaesthetic in aquaculture can be considered to be safe in terms of genotoxicity.
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页码：163 / 168
页数：6
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