A new dammarane type triterpene glucoside from the aerial parts of Gouania longipetala (Rhamnaceae)

被引：1

作者：

Desire, Soh ^{[1
,2
,3
]}

Ernestine, Nkwengoua ^{[2
]}

Bruno, Tchebemou Bakang ^{[2
]}

Lazare, Sidjui Sidjui ^{[3
,4
]}

Ulrich, Dzo Defokou ^{[2
]}

Lateef, Mehreen ^{[5
]}

Schneider, Bernd ^{[6
]}

Ali, Muhammad Shaiq ^{[3
]}

Barthelemy, Nyasse ^{[2
]}

机构：

[1] Univ Bamenda, TRU, Higher Teacher Training Coll, Dept Chem, Bamenda, Cameroon

[2] Univ Yaounde I, Dept Organ Chem, Fac Sci, Lab Med Chem & Pharmacognosy, Yaounde, Cameroon

[3] Univ Karachi, ICCBS, HEJ Res Inst Chem, Karachi, Pakistan

[4] Univ Yaounde I, TRU, Inst Med Res & Med Plant Studies, Fac Sci,Dept Organ Chem, Yaounde, Cameroon

[5] Bahria Univ Med & Dent Coll, Multidisciplinary Res Lab, Karachi, Pakistan

[6] Max Planck Inst Chem Ecol, Jena, Germany

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 19期

关键词：

Gouania longipetala; 3-O-beta-D-glucopyranosyl gouanogenin A; antioxidant activity; urease inhibition; SEMEN-SEU-FRUCTUS; ABSOLUTE STEREOSTRUCTURES; CHEMICAL-CONSTITUENTS; ANTIOXIDANT; LUPEOL; GLYCOSIDES; SAPONINS; EXTRACT; LEAVES; FRUIT;

D O I：

10.1080/14786419.2019.1690483

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

3-O-beta-D-glucopyranosyl gouanogenin A (1), a new naturally occurring dammarane class of triterpene glucoside, has been isolated from the aerial parts of Gouania longipetala along with six known secondary metabolites 2-7. Their structure was elucidated through spectroscopic data including 1 D- and 2 D-NMR. The compounds 1 and 6 showed significant antioxidant potential in DPPH radical scavenging assay. On the other hand, the compound 4 revealed potent inhibitory potential against the enzyme urease, while 1 and 3 were significantly active.

引用

页码：3192 / 3203

页数：12

共 30 条

[1]

Abbiw D.K., 1990, USEFUL PLANTS GHANA, P154

[2]

Abdullahi S.M., 2013, Sch Acad J Biosci Sch Acad J Biosci, V1, P18

[3] Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae [J].

Aguirre, Maria C. ;

Delporte, Carla ;

Backhouse, Nadine ;

Erazo, Silvia ;

Letelier, Maria Eugenia ;

Cassels, Bruce K. ;

Silva, Ximena ;

Alegria, Sergio ;

Negrete, Rosa .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (16) :5673-5677

[4]

[Anonymous], 1985, USEFUL PLANTS W TROP

[5] Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells [J].

Basar, Norazah ;

Oridupa, Olayinka Ayotunde ;

Ritchie, Kenneth J. ;

Nahar, Lutfun ;

Osman, Nashwa Mostafa M. ;

Stafford, Angela ;

Kushiev, Habibjon ;

Kan, Asuman ;

Sarker, Satyajit D. .

PHYTOTHERAPY RESEARCH, 2015, 29 (06) :944-948

[6]

Burns D, 2000, MAGN RESON CHEM, V38, P488, DOI 10.1002/1097-458X(200007)38:7<488::AID-MRC704>3.0.CO

[7]

2-G

[8] In vivo estrogenic-like activities of Gouania longipetala Hemsl. (Rhamnaceae) bark extracts in a post-menopause-like model of ovariectomized Wistar rats [J].

Desire, Dzeufiet Djomeni Paul ;

Sandrine, Mengue Ngadena Yolande ;

Claude, Bilanda Danielle ;

Mireille, Kameni ;

Bibi-Farouck, Aboubakar Oumarou ;

Theophile, Dimo ;

Pierre, Kamtchouing .

JOURNAL OF ETHNOPHARMACOLOGY, 2015, 168 :122-128

[9] Chemical constituents from Gouania longipetala and Glyphaea brevis [J].

Ekuadzi, E. ;

Dickson, R. A. ;

Fleischer, T. C. ;

Amponsah, I. K. ;

Pistorius, D. ;

Oberer, L. .

NATURAL PRODUCT RESEARCH, 2014, 28 (15) :1210-1213

[10] ANTIBACTERIAL, ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF GOUANIA LONGIPETALA HEMSL [J].

Ekuadzi, Edmund ;

Dickson, Rita A. ;

Fleischer, Theophilus C. .

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2012, 3 (05) :1300-1305

← 1 2 3 →