Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes

被引：21

作者：

Blair, Connor M. ^{[1
]}

Baillie, George S. ^{[1
]}

机构：

[1] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2019年 / 47卷

基金：

英国医学研究理事会;

关键词：

SIGNALING SCAFFOLD PROTEINS; BETA(2)-ADRENERGIC RECEPTORS; PKA PHOSPHORYLATION; BETA-ARRESTIN; KINASE; PEPTIDE; PDE4D5; HSP20; ACTIVATION; DEGRADATION;

D O I：

10.1042/BST20190252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spatio-temporal regulation of localised cAMP nanodomains is highly dependent upon the compartmentalised activity of phosphodiesterase (PDE) cyclic nucleotide degrading enzymes. Strategically positioned PDE-protein complexes are pivotal to the homeostatic control of cAMP-effector protein activity that in turn orchestrate a wide range of cellular signalling cascades in a variety of cells and tissue types. Unsurprisingly, dysregulated PDE activity is central to the pathophysiology of many diseases warranting the need for effective therapies that target PDEs selectively. This short review focuses on the importance of activating compartmentalised cAMP signalling by displacing the PDE component of signalling complexes using cell-permeable peptide disrupters

引用

页码：1405 / 1414

页数：10

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