Diagnostic Performance of an Electronic Nose, Fractional Exhaled Nitric Oxide, and Lung Function Testing in Asthma

被引:157
作者
Montuschi, Paolo [1 ]
Santonico, Marco [2 ]
Mondino, Chiara [4 ]
Pennazza, Giorgio [3 ]
Mantini, Giulia [2 ]
Martinelli, Eugenio [2 ]
Capuano, Rosamaria [2 ]
Ciabattoni, Giovanni [5 ]
Paolesse, Roberto [2 ]
Di Natale, Corrado [2 ]
Barnes, Peter J. [6 ]
D'Amico, Arnaldo [2 ]
机构
[1] Univ Cattolica Sacro Cuore, Fac Med, Dept Pharmacol, I-00168 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Elect Engn, I-00173 Rome, Italy
[3] Univ Campus Biomed, Fac Engn, Rome, Italy
[4] IDI, Dept Immunodermatol, Rome, Italy
[5] Univ G dAnnunzio, Fac Pharm, Dept Drug Sci, Chieti, Italy
[6] Univ London Imperial Coll Sci Technol & Med, Sch Med, Airway Dis Sect, Natl Heart & Lung Inst, London, England
关键词
VOLATILE ORGANIC-COMPOUNDS; IDENTIFICATION; CANCER; METALLOPORPHYRINS; DISCRIMINATION; BREATH; ARRAY;
D O I
10.1378/chest.09-1836
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Background: Analysis of exhaled breath by biosensors discriminates between patients with asthma and healthy subjects. An electronic nose consists of a chemical sensor array for the detection of volatile organic compounds (VOCs) and an algorithm for pattern recognition. We compared the diagnostic performance of a prototype of an electronic nose with lung function tests and fractional exhaled nitric oxide (FENO) in patients with atopic asthma. Methods: A cross-sectional study was undertaken in 27 patients with intermittent and persistent mild asthma and in 24 healthy subjects. Two procedures for collecting exhaled breath were followed to study the differences between total and alveolar air. Seven patients with asthma and seven healthy subjects participated in a study with mass spectrometry (MS) fingerprinting as an independent technique for assessing between group discrimination. Classification was based on principal component analysis and a feed-forward neural network. Results: The best results were obtained when the electronic nose analysis was performed on alveolar air. Diagnostic performance for electronic nose, FENO, and lung function testing was 87.5%, 79.2%, and 70.8%, respectively. The combination of electronic nose and FENO had the highest diagnostic performance for asthma (95.8%). MS fingerprints of VOCs could discriminate between patients with asthma and healthy subjects. Conclusions: The electronic nose has a high diagnostic performance that can be increased when combined with FENO. Large studies are now required to definitively establish the diagnostic performance of the electronic nose. Whether this integrated noninvasive approach will translate into an early diagnosis of asthma has to be clarified. Trial registration: EUDRACT https://eudralink.emea.europa.eu; Identifier: 2007-000890-51; and clinicaltrials.gov; Identifier: NCT00819676. CHEST 2010; 137(4):790-796
引用
收藏
页码:790 / 796
页数:7
相关论文
共 25 条
[1]  
[Anonymous], 1999, Am J Respir Crit Care Med, V160, P2104
[2]  
[Anonymous], 2007, Applied multivariate statistical analysis, sixth edition M
[3]  
[Anonymous], 2006, Pattern recognition and machine learning
[4]   Identification of melanoma with a gas sensor array [J].
D'Amico, A. ;
Bono, R. ;
Pennazza, G. ;
Santonico, M. ;
Mantini, G. ;
Bernabei, M. ;
Zarlenga, M. ;
Roscioni, C. ;
Martinelli, E. ;
Paolesse, R. ;
Di Natale, C. .
SKIN RESEARCH AND TECHNOLOGY, 2008, 14 (02) :226-236
[5]   Olfactory systems for medical applications [J].
D'Amico, A. ;
Di Natale, C. ;
Paolesse, R. ;
Macagnano, A. ;
Martinelli, E. ;
Pennazza, G. ;
Santonico, A. ;
Bernabei, M. ;
Roscioni, C. ;
Galluccio, G. ;
Bono, R. ;
Finazzi Agro, E. ;
Rullo, S. .
SENSORS AND ACTUATORS B-CHEMICAL, 2008, 130 (01) :458-465
[6]   Metalloporphyrins as basic material for volatile sensitive sensors [J].
D'Amico, A ;
Di Natale, C ;
Paolesse, R ;
Macagnano, A ;
Mantini, A .
SENSORS AND ACTUATORS B-CHEMICAL, 2000, 65 (1-3) :209-215
[7]   Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors [J].
Di Natale, C ;
Macagnano, A ;
Martinelli, E ;
Paolesse, R ;
D'Arcangelo, G ;
Roscioni, C ;
Finazzi-Agrò, A ;
D'Amico, A .
BIOSENSORS & BIOELECTRONICS, 2003, 18 (10) :1209-1218
[8]   Metalloporphyrins based artificial olfactory receptors [J].
Di Natale, Corrado ;
Paolesse, Roberto ;
D'Amico, Amaldo .
SENSORS AND ACTUATORS B-CHEMICAL, 2007, 121 (01) :238-246
[9]   An electronic nose in the discrimination of patients with asthma and controls [J].
Dragonieri, Silvano ;
Schot, Robert ;
Mertens, Bart J. A. ;
Le Cessie, Saskia ;
Gauw, Stefanie A. ;
Spanevello, Antonio ;
Resta, Onofrio ;
Willard, Nico P. ;
Vink, Teunis J. ;
Rabe, Klaus F. ;
Bel, Elisabeth H. ;
Sterk, Peter J. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (04) :856-862
[10]   An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD [J].
Dragonieri, Silvano ;
Annema, Jouke T. ;
Schot, Robert ;
van der Schee, Marc P. C. ;
Spanevello, Antonio ;
Carratu, Pierluigi ;
Resta, Onofrio ;
Rabe, Klaus F. ;
Sterk, Peter J. .
LUNG CANCER, 2009, 64 (02) :166-170