Src activation in the induction of long-term potentiation in CA1 hippocampal neurons

被引：271
作者：
Lu, YM
Roder, JC [1 ]
Davidow, J
Salter, MW
机构：
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada
[3] Hosp Sick Children, Div Neurosci, Toronto, ON M5G 1X8, Canada
[4] Univ Toronto, Dept Physiol, Toronto, ON M5G 1X8, Canada
来源：
SCIENCE | 1998年 / 279卷 / 5355期
关键词：
D O I：
10.1126/science.279.5355.1363
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Long-term potentiation (LTP) is an activity-dependent strengthening of synaptic efficacy that is considered to be a model of learning and memory. Protein tyrosine phosphorylation is necessary io induce LTP. Here, induction of LTP in CA1 pyramidal cells of rats was prevented by blocking the tyrosine kinase Src, and Src activity was increased by stimulation producing LTP. Directly activating Sre in the postsynaptic neuron enhanced excitatory synaptic responses, occluding LTP. Src-induced enhancement of alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor-mediated synaptic responses required raised intracellular Ca2+ and N-methyl-D-aspartate (NMDA) receptors. Thus, Sre activation is necessary and sufficient for inducing LTP and may function by up-regulating NMDA receptors.
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收藏
页码：1363 / 1367
页数：5
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