Expression of the vldl receptor is upregulated by cell differentiation in HL-60 cells

被引：0

作者：

Takahashi, S ^{[1
]}

Kohno, M ^{[1
]}

Kosaka, S ^{[1
]}

Masamura, K ^{[1
]}

Suzuki, J ^{[1
]}

Oida, K ^{[1
]}

Yamamoto, T ^{[1
]}

Miyamori, I ^{[1
]}

机构：

[1] Fukui Med Univ, Dept Internal Med 3, Fukui 9101193, Japan

来源：

LIPOPROTEIN METABOLISM AND ATHEROGENESIS | 2000年

关键词：

VLDL receptor; LDL receptor; HL-60; cells; differentiation;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HL-60 cells were induced to differentiate into monocyte-macrophage, The level of VLDL receptor mRNA and protein increased in a dose-dependent and time dependent manner after 1 alpha, 25-dihydroxyvitamin D-3 administration. Whereas the level of LDL receptor mRNA was not altered. On the other hand, VLDL receptor mRNA level was not changed during differentiation of the cells into macrophagic cells with phorbol 12-myristate 13-acetate (PMA). Different levels of VLDL receptor induction in the differentiation of HL-60 cells could provide significant information to investigate the regulation mechanisms for induction and function of VLDL receptor.

引用

页码：146 / 148

页数：3

共 7 条

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