NHC-Ir(I) complexes derived from 5,6-dinitrobenzimidazole. Synthesis, characterization and preliminary evaluation of their in vitro anticancer activity

被引：18
|
作者：
Sanchez-Mora, Arturo [1 ]
Valdes, Hugo [1 ]
Teresa Ramirez-Apan, Maria [1 ]
Nieto-Camacho, Antonio [1 ]
Hernandez-Ortega, Simon [1 ]
Canseco-Gonzalez, Daniel [2 ]
Morales-Morale, David [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Ciudad De Mexico 04510, Mexico
[2] Univ Autonoma Chapingo, CONACYT Lab Nacl Invest & Serv Agroalimentario &, Texcoco De Mora, Mexico
来源：
INORGANICA CHIMICA ACTA | 2019年 / 496卷
关键词：
Cancer; Cytotoxic activity; N-heterocyclic carbene; Iridium complexes; Fluorinated complexes; Antioxidant properties; HETEROCYCLIC CARBENE COMPLEXES; IRIDIUM(III) COMPLEXES; RUTHENIUM(II) COMPLEXES; NATURAL-PRODUCTS; METAL-COMPLEXES; CANCER-CELLS; GOLD(I); AGENTS; LIGANDS; RHODIUM(I);
D O I：
10.1016/j.ica.2019.119061
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The design, synthesis, characterization and in vitro anticancer activity of a series of Ir(I) NHC complexes derived from 5,6-dinitrobenzimidazole is reported. The evaluation was performed in five human cancer cell-lines, namely glioblastoma (U-251), prostatic adenocarcinoma (PC-3), colorectal adenocarcinoma (HCT-15), mammary adenocarcinoma (MCF-7) and lung adenocarcinoma (SKLU-7), including healthy cells of African green monkey kidney (COS-7) for comparative purposes. The complexes exhibited better activity in comparison with the corresponding NHC ligand precursors. In particular, complex (4a) exhibited a good performance against PC-3 and SKLU-1 with IC50 values of 10.6 +/- 0.9 mu M and 10.4 +/- 1.5 mu M, respectively.
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页数：8
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