A simple cellular automaton model for influenza A viral infections

被引：117

作者：

Beauchemin, C ^{[1
]}

Samuel, J

Tuszynski, J

机构：

[1] Univ Alberta, Dept Phys, Edmonton, AB T6G 2J1, Canada

[2] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2005年 / 232卷 / 02期

关键词：

cellular automation; immune system; modelling; influenza; spatial inhomogeneities;

D O I：

10.1016/j.jtbi.2004.08.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viral kinetics have been extensively studied in the past through the use of spatially homogeneous ordinary differential equations describing the time evolution of the diseased state. However, spatial characteristics such as localized populations of dead cells might adversely affect the spread of infection, similar to the manner in which a counter-fire can stop a forest fire from spreading. In order to investigate the influence of spatial heterogeneities on viral spread, a simple 2-D cellular automaton (CA) model of a viral infection has been developed. In this initial phase of the investigation, the CA model is validated against clinical immunological data for uncomplicated influenza A infections. Our results will be shown and discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：223 / 234

页数：12

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