Efficient synthesis of 5-nitro-benzo[b]furans via 2-bromo-4-nitro-phenyl acetates

被引：21

作者：

Bochicchio, Antonella ^{[1
]}

Chiummiento, Lucia ^{[1
]}

Funicello, Maria ^{[1
]}

Lopardo, Maria Teresa ^{[1
]}

Lupattelli, Paolo ^{[1
]}

机构：

[1] Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 21期

关键词：

5-Nitro-benzo[b]furans; 2-Br-phenyl acetates; Sonogashira reaction; Pd catalyst; Heteroannulation; ONE-POT SYNTHESIS; COPPER-FREE; COUPLING REACTIONS; BENZOFURANS; 2-ALKYNYLPHENOLS; AGGREGATION; DERIVATIVES; CYCLIZATION; CHEMISTRY; CATALYSTS;

D O I：

10.1016/j.tetlet.2010.03.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acetylation/Sonogashira cross-coupling reaction/cyclization has been carried out in one-pot using a Na2PdCl4/2-(di-tert-butylphosphino)-N-phenylindole/Cul system in TMEDA to give 5-nitro-2-substituted benzo[b]furans in excellent yields. We also describe the extension of this method to 4-EWG-2-bromophenols obtaining 2,5-disubstituted-benzo[b]furans in good yields. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2824 / 2827

页数：4

共 49 条

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