The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder

被引：27
作者：
Szobot, CM
Ketzer, C
Cunha, RD
Parente, MA
Langleben, DD
Acton, PD
Kapczinski, F
Rohde, LAP
机构：
[1] Univ Fed Rio Grande do Sul, Dept Psychiat, BR-90046900 Porto Alegre, RS, Brazil
[2] Hosp Clin, Nucl Med Serv, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Dept Psychol, BR-90046900 Porto Alegre, RS, Brazil
[4] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2003年 / 30卷 / 03期
关键词：
attention-deficit/hyperactivity; disorder; ADHD; parietal cortex; SPET; methylphenidate;
D O I：
10.1007/s00259-002-1082-0
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer (Tc-99m-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD.
引用
收藏
页码：423 / 426
页数：4
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