Assessment of the optimization of the conditions of mitomycin C intravesical instillation completion in the setting of non-muscle invasive bladder cancer treatment

被引:2
作者
Lailler, G. [1 ,2 ]
Neuzillet, Y. [1 ,2 ]
Rouanne, M. [1 ,2 ]
Lebret, T. [1 ,2 ]
机构
[1] Hop Foch, Serv Urol & Transplantat Renale, F-92151 Suresnes, France
[2] Univ Versailles St Quentin Yvelines, UFR Sci Sante Simone Veil, 40 Rue Worth, F-92150 Suresnes, France
来源
PROGRES EN UROLOGIE | 2016年 / 26卷 / 02期
关键词
Non-muscle invasive bladder cancer; Instillation; Mitomycin C; Alkalinization; Fluid restriction;
D O I
10.1016/j.purol.2015.10.005
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective. - The efficacy of intravesical instillation of mitomycin C (MMC) requires alkalinisation and concentration of urine before each instillation. The objective of the study was to assess compliance and effectiveness of urine alkalinazation and fluid restriction protocols in patients treated with intravesical instillations of MMC for TVNIM. Material et method. - Descriptive prospective epidemiological study in all patients consecutively treated with intravesical instillations of MMC for non-muscle invasive bladder cancer (NMIBC). Patients should be advised to drink 2 liters of water from Vichy and to perform fluid restriction the day before the instillations. Before each instillation, a questionnaire on the implementation of these measures was filled, density and pH were determined by urinalysis strips. Results. - On 126 questionnaires fulfilled, 117 patients (93%) and 106 patients (84%) reported having made alkalinization and fluid restriction, respectively. Ninety-one of patients (78%) reported having performed alkalinization had a pH greater than or equal to 6.5 and the mean urinary pH was 6.94 vs. 5.94 in patients stating not to have made alkalizing (P=0.0001). No significant differences in urine density according to fluid restriction was found. Conclusion. - The observance of the instructions regarding urine alkalinization before MMC instillations was satisfactory and has achieved a sufficiently high urinary pH to prevent degradation of the product in 91% of cases. Conversely, the fluid restriction was not followed closely and has not shown its effectiveness on the concentration of urine. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:79 / 82
页数:4
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