Age-related effect of ritanserin on the sleep-waking phases in rats

被引：11

作者：

Kirov, R ^{[1
]}

Moyanova, S ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Physiol, BU-1113 Sofia, Bulgaria

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 1998年 / 93卷 / 3-4期

关键词：

ritanserin; 5-HT2; receptors; sleep-waking phases; EEG; rats; aging;

D O I：

10.3109/00207459808986432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The age-related effect of the specific 5-hpdroxytrypramine-2A/2C (5-HT2A/2C) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middle-aged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.

引用

页码：265 / 278

页数：14

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